Creating Shareable Clinical Decision Support Rules for a Pharmacogenomics Clinical Guideline Using Structured Knowledge Representation

Margaret K. Linan, Davide Sottara, Robert R. Freimuth

    Research output: Contribution to journalArticle

    1 Citation (Scopus)

    Abstract

    Pharmacogenomics (PGx) guidelines contain drug-gene relationships, therapeutic and clinical recommendations from which clinical decision support (CDS) rules can be extracted, rendered and then delivered through clinical decision support systems (CDSS) to provide clinicians with just-in-time information at the point of care. Several tools exist that can be used to generate CDS rules that are based on computer interpretable guidelines (CIG), but none have been previously applied to the PGx domain. We utilized the Unified Modeling Language (UML), the Health Level 7 virtual medical record (HL7 vMR) model, and standard terminologies to represent the semantics and decision logic derived from a PGx guideline, which were then mapped to the Health eDecisions (HeD) schema. The modeling and extraction processes developed here demonstrate how structured knowledge representations can be used to support the creation of shareable CDS rules from PGx guidelines.

    Original languageEnglish (US)
    Pages (from-to)1985-1994
    Number of pages10
    JournalAMIA ... Annual Symposium proceedings. AMIA Symposium
    Volume2015
    StatePublished - Jan 1 2015

    Fingerprint

    Clinical Decision Support Systems
    Pharmacogenetics
    Guidelines
    Health Level Seven
    Point-of-Care Systems
    Semantics
    Terminology
    Medical Records
    Language
    Health
    Pharmaceutical Preparations
    Genes

    ASJC Scopus subject areas

    • Medicine(all)

    Cite this

    Creating Shareable Clinical Decision Support Rules for a Pharmacogenomics Clinical Guideline Using Structured Knowledge Representation. / Linan, Margaret K.; Sottara, Davide; Freimuth, Robert R.

    In: AMIA ... Annual Symposium proceedings. AMIA Symposium, Vol. 2015, 01.01.2015, p. 1985-1994.

    Research output: Contribution to journalArticle

    @article{5d440b877ba247f9a62a65ece72e3088,
    title = "Creating Shareable Clinical Decision Support Rules for a Pharmacogenomics Clinical Guideline Using Structured Knowledge Representation",
    abstract = "Pharmacogenomics (PGx) guidelines contain drug-gene relationships, therapeutic and clinical recommendations from which clinical decision support (CDS) rules can be extracted, rendered and then delivered through clinical decision support systems (CDSS) to provide clinicians with just-in-time information at the point of care. Several tools exist that can be used to generate CDS rules that are based on computer interpretable guidelines (CIG), but none have been previously applied to the PGx domain. We utilized the Unified Modeling Language (UML), the Health Level 7 virtual medical record (HL7 vMR) model, and standard terminologies to represent the semantics and decision logic derived from a PGx guideline, which were then mapped to the Health eDecisions (HeD) schema. The modeling and extraction processes developed here demonstrate how structured knowledge representations can be used to support the creation of shareable CDS rules from PGx guidelines.",
    author = "Linan, {Margaret K.} and Davide Sottara and Freimuth, {Robert R.}",
    year = "2015",
    month = "1",
    day = "1",
    language = "English (US)",
    volume = "2015",
    pages = "1985--1994",
    journal = "AMIA ... Annual Symposium proceedings / AMIA Symposium. AMIA Symposium",
    issn = "1559-4076",
    publisher = "American Medical Informatics Association",

    }

    TY - JOUR

    T1 - Creating Shareable Clinical Decision Support Rules for a Pharmacogenomics Clinical Guideline Using Structured Knowledge Representation

    AU - Linan, Margaret K.

    AU - Sottara, Davide

    AU - Freimuth, Robert R.

    PY - 2015/1/1

    Y1 - 2015/1/1

    N2 - Pharmacogenomics (PGx) guidelines contain drug-gene relationships, therapeutic and clinical recommendations from which clinical decision support (CDS) rules can be extracted, rendered and then delivered through clinical decision support systems (CDSS) to provide clinicians with just-in-time information at the point of care. Several tools exist that can be used to generate CDS rules that are based on computer interpretable guidelines (CIG), but none have been previously applied to the PGx domain. We utilized the Unified Modeling Language (UML), the Health Level 7 virtual medical record (HL7 vMR) model, and standard terminologies to represent the semantics and decision logic derived from a PGx guideline, which were then mapped to the Health eDecisions (HeD) schema. The modeling and extraction processes developed here demonstrate how structured knowledge representations can be used to support the creation of shareable CDS rules from PGx guidelines.

    AB - Pharmacogenomics (PGx) guidelines contain drug-gene relationships, therapeutic and clinical recommendations from which clinical decision support (CDS) rules can be extracted, rendered and then delivered through clinical decision support systems (CDSS) to provide clinicians with just-in-time information at the point of care. Several tools exist that can be used to generate CDS rules that are based on computer interpretable guidelines (CIG), but none have been previously applied to the PGx domain. We utilized the Unified Modeling Language (UML), the Health Level 7 virtual medical record (HL7 vMR) model, and standard terminologies to represent the semantics and decision logic derived from a PGx guideline, which were then mapped to the Health eDecisions (HeD) schema. The modeling and extraction processes developed here demonstrate how structured knowledge representations can be used to support the creation of shareable CDS rules from PGx guidelines.

    UR - http://www.scopus.com/inward/record.url?scp=85045028886&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=85045028886&partnerID=8YFLogxK

    M3 - Article

    C2 - 26958298

    AN - SCOPUS:85045028886

    VL - 2015

    SP - 1985

    EP - 1994

    JO - AMIA ... Annual Symposium proceedings / AMIA Symposium. AMIA Symposium

    JF - AMIA ... Annual Symposium proceedings / AMIA Symposium. AMIA Symposium

    SN - 1559-4076

    ER -