TY - JOUR
T1 - Creating pathways towards aromatic building blocks and fine chemicals
AU - Thompson, Brian
AU - Machas, Michael
AU - Nielsen, David
N1 - Funding Information:
D.R.N. is supported by the National Science Foundation ( CBET-1159200 , CBET-1511637 ) and ASU LightWorks.
Publisher Copyright:
© 2015 Elsevier Ltd.
PY - 2015/12/1
Y1 - 2015/12/1
N2 - Aromatic compounds represent a broad class of chemicals with a range of industrial applications, all of which are conventionally derived from petroleum feedstocks. However, owing to a diversity of available pathway precursors along with natural and engineered enzyme 'parts', microbial cell factories can be engineered to create alternative, renewable routes to many of the same aromatic products. Drawing from the latest tools and strategies in metabolic engineering and synthetic biology, such efforts are becoming an increasingly systematic practice, while continued efforts promise to open new doors to an ever-expanding range and diversity of renewable chemical and material products. This short review will highlight recent and notable achievements related for the microbial production of aromatic chemicals.
AB - Aromatic compounds represent a broad class of chemicals with a range of industrial applications, all of which are conventionally derived from petroleum feedstocks. However, owing to a diversity of available pathway precursors along with natural and engineered enzyme 'parts', microbial cell factories can be engineered to create alternative, renewable routes to many of the same aromatic products. Drawing from the latest tools and strategies in metabolic engineering and synthetic biology, such efforts are becoming an increasingly systematic practice, while continued efforts promise to open new doors to an ever-expanding range and diversity of renewable chemical and material products. This short review will highlight recent and notable achievements related for the microbial production of aromatic chemicals.
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U2 - 10.1016/j.copbio.2015.07.004
DO - 10.1016/j.copbio.2015.07.004
M3 - Review article
C2 - 26264997
AN - SCOPUS:84938912169
SN - 0958-1669
VL - 36
SP - 1
EP - 7
JO - Current Opinion in Biotechnology
JF - Current Opinion in Biotechnology
ER -