COX-2: A target for colon cancer prevention

Lawrence J. Marnett, Raymond N. DuBois

    Research output: Contribution to journalReview articlepeer-review

    281 Scopus citations

    Abstract

    Disease prevention is one area that both public and governmental agencies strongly support owing to its potential for an improved lifestyle and a reduction in health care costs. In this review, we focus on the clinical development of one target for cancer prevention, the COX-2 enzyme. This provides an excellent example of how basic research in biochemistry and pharmacology can lead to translational studies and eventually to approval of a drug by the FDA for use as a chemopreventive agent in humans. It is hoped that, as the genome sequence is understood more clearly, other targets will emerge that will provide even more effective drugs for future cancer prevention.

    Original languageEnglish (US)
    Pages (from-to)55-80
    Number of pages26
    JournalAnnual Review of Pharmacology and Toxicology
    Volume42
    DOIs
    StatePublished - 2002

    Keywords

    • Cancer
    • Cyclooxygenase
    • NSAIDs
    • Prevention
    • Prostaglandins

    ASJC Scopus subject areas

    • Toxicology
    • Pharmacology

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