COX-2: A molecular target for colorectal cancer prevention

Joanne R. Brown, Raymond N. DuBois

    Research output: Contribution to journalArticlepeer-review

    431 Scopus citations

    Abstract

    Cyclooxygenase (COX), a key enzyme in the prostanoid biosynthetic pathway, has received considerable attention due to its role in human cancers. Observational and randomized controlled studies in many different population cohorts and settings have demonstrated protective effects of nonsteroidal anti-inflammatory drugs (NSAIDs; the inhibitors of COX activity) for colorectal cancers (CRCs). COX-2, the inducible isoform of cyclooxygenase, is overexpressed in early and advanced CRC tissues, which portends a poor prognosis. Experimental studies have thus identified important mechanisms and pathways by which COX-2 plays an important role in carcinogenesis. Selective COX-2 inhibitors have been approved for use as adjunctive therapy for patients with familial polyposis. The role of COX-2 inhibitors is currently being evaluated for use in wider populations.

    Original languageEnglish (US)
    Pages (from-to)2840-2855
    Number of pages16
    JournalJournal of Clinical Oncology
    Volume23
    Issue number12
    DOIs
    StatePublished - Apr 20 2005

    ASJC Scopus subject areas

    • Oncology
    • Cancer Research

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