Abstract
Background: The relation between childhood trauma and chronic pain and emotional symptoms in adulthood has been well-documented, although physiological mechanisms mediating this link have not been elaborated. Purpose: This study examined the mediating role of cortisol profile in the linkage between childhood maltreatment and pain and emotional symptoms in individuals with fibromyalgia (FM). Methods: One hundred seventy-nine adults with FM first provided retrospective self-reports of childhood maltreatment, then attended a standardized session during which cortisol was sampled across 1.5 hours and, subsequently, completed assessments of daily pain, depressive symptoms, and anxiety. Latent growth curve modeling estimated the hypothesized mediation models. Results: Childhood neglect predicted a flattened cortisol profile, which, in turn, predicted elevated daily pain and emotional symptoms. The cortisol profile partially mediated the neglect-symptom relation. Conclusions: Early maltreatment may exert enduring effects on endocrine regulation that contributes to pain and emotional symptoms in adults with chronic pain.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 87-97 |
| Number of pages | 11 |
| Journal | Annals of Behavioral Medicine |
| Volume | 50 |
| Issue number | 1 |
| DOIs | |
| State | Published - Feb 1 2016 |
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Keywords
- Anxiety
- Childhood Maltreatment
- Cortisol
- Depression
- Fibromyalgia
- Pain
ASJC Scopus subject areas
- Psychology(all)
- Psychiatry and Mental health
Cite this
Cortisol Profile Mediates the Relation Between Childhood Neglect and Pain and Emotional Symptoms among Patients with Fibromyalgia. / Yeung, Ellen W.; Davis, Mary; Ciaramitaro, Marissa C.
In: Annals of Behavioral Medicine, Vol. 50, No. 1, 01.02.2016, p. 87-97.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cortisol Profile Mediates the Relation Between Childhood Neglect and Pain and Emotional Symptoms among Patients with Fibromyalgia
AU - Yeung, Ellen W.
AU - Davis, Mary
AU - Ciaramitaro, Marissa C.
PY - 2016/2/1
Y1 - 2016/2/1
N2 - Background: The relation between childhood trauma and chronic pain and emotional symptoms in adulthood has been well-documented, although physiological mechanisms mediating this link have not been elaborated. Purpose: This study examined the mediating role of cortisol profile in the linkage between childhood maltreatment and pain and emotional symptoms in individuals with fibromyalgia (FM). Methods: One hundred seventy-nine adults with FM first provided retrospective self-reports of childhood maltreatment, then attended a standardized session during which cortisol was sampled across 1.5 hours and, subsequently, completed assessments of daily pain, depressive symptoms, and anxiety. Latent growth curve modeling estimated the hypothesized mediation models. Results: Childhood neglect predicted a flattened cortisol profile, which, in turn, predicted elevated daily pain and emotional symptoms. The cortisol profile partially mediated the neglect-symptom relation. Conclusions: Early maltreatment may exert enduring effects on endocrine regulation that contributes to pain and emotional symptoms in adults with chronic pain.
AB - Background: The relation between childhood trauma and chronic pain and emotional symptoms in adulthood has been well-documented, although physiological mechanisms mediating this link have not been elaborated. Purpose: This study examined the mediating role of cortisol profile in the linkage between childhood maltreatment and pain and emotional symptoms in individuals with fibromyalgia (FM). Methods: One hundred seventy-nine adults with FM first provided retrospective self-reports of childhood maltreatment, then attended a standardized session during which cortisol was sampled across 1.5 hours and, subsequently, completed assessments of daily pain, depressive symptoms, and anxiety. Latent growth curve modeling estimated the hypothesized mediation models. Results: Childhood neglect predicted a flattened cortisol profile, which, in turn, predicted elevated daily pain and emotional symptoms. The cortisol profile partially mediated the neglect-symptom relation. Conclusions: Early maltreatment may exert enduring effects on endocrine regulation that contributes to pain and emotional symptoms in adults with chronic pain.
KW - Anxiety
KW - Childhood Maltreatment
KW - Cortisol
KW - Depression
KW - Fibromyalgia
KW - Pain
UR - http://www.scopus.com/inward/record.url?scp=84957430559&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84957430559&partnerID=8YFLogxK
U2 - 10.1007/s12160-015-9734-z
DO - 10.1007/s12160-015-9734-z
M3 - Article
C2 - 26404060
AN - SCOPUS:84957430559
VL - 50
SP - 87
EP - 97
JO - Annals of Behavioral Medicine
JF - Annals of Behavioral Medicine
SN - 0883-6612
IS - 1
ER -