Cortisol in mother's milk across lactation reflects maternal life history and predicts infant temperament

Katherine Hinde, Amy L. Skibiel, Alison B. Foster, Laura Del Rosso, Sally P. Mendoza, John P. Capitanio

Research output: Contribution to journalArticle

77 Citations (Scopus)

Abstract

The maternal environment exerts important influences on offspring mass/growth, metabolism, reproduction, neurobiology, immune function, and behavior among birds, insects, reptiles, fish, and mammals. For mammals, mother's milk is an important physiological pathway for nutrient transfer and glucocorticoid signaling that potentially influences offspring growth and behavioral phenotype. Glucocorticoids in mother's milk have been associated with offspring behavioral phenotype in several mammals, but studies have been handicapped by not simultaneously evaluating milk energy density and yield. This is problematic as milk glucocorticoids and nutrients likely have simultaneous effects on offspring phenotype. We investigated mother's milk and infant temperament and growth in a cohort of rhesus macaque (Macaca mulatta) mother-infant dyads at the California National Primate Research Center (N = 108). Glucocorticoids in mother's milk, independent of available milk energy, predicted a more Nervous, less Confident temperament in both sons and daughters. We additionally found sex differences in the windows of sensitivity and the magnitude of sensitivity to maternalorigin glucocorticoids. Lower parity mothers produced milk with higher cortisol concentrations. Lastly, higher cortisol concentrations in milk were associated with greater infant weight gain across time. Taken together, these results suggest that mothers with fewer somatic resources, even in captivity, may be "programming" through cortisol signaling, behaviorally cautious offspring that prioritize growth. Glucocorticoids ingested through milk may importantly contribute to the assimilation of available milk energy, development of temperament, and orchestrate, in part, the allocation of maternal milk energy between growth and behavioral phenotype.

Original languageEnglish (US)
Pages (from-to)269-281
Number of pages13
JournalBehavioral Ecology
Volume26
Issue number1
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

Fingerprint

temperament
lactation
milk
cortisol
life history
glucocorticoids
phenotype
mammal
mammals
Macaca mulatta
energy
infant
maternal milk
neurophysiology
energy density
nutrients
nutrient
parity (reproduction)
captivity
gender differences

Keywords

  • Behavioral phenotype
  • Breast milk composition
  • Developmental programming
  • Glucocorticoids
  • Life-history theory
  • Personality

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Ecology, Evolution, Behavior and Systematics

Cite this

Cortisol in mother's milk across lactation reflects maternal life history and predicts infant temperament. / Hinde, Katherine; Skibiel, Amy L.; Foster, Alison B.; Rosso, Laura Del; Mendoza, Sally P.; Capitanio, John P.

In: Behavioral Ecology, Vol. 26, No. 1, 01.01.2015, p. 269-281.

Research output: Contribution to journalArticle

Hinde, Katherine ; Skibiel, Amy L. ; Foster, Alison B. ; Rosso, Laura Del ; Mendoza, Sally P. ; Capitanio, John P. / Cortisol in mother's milk across lactation reflects maternal life history and predicts infant temperament. In: Behavioral Ecology. 2015 ; Vol. 26, No. 1. pp. 269-281.
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