Cortisol awakening response and additive serotonergic genetic risk interactively predict depression in two samples: The 2019 Donald F. Klein Early Career Investigator Award Paper

Suzanne Vrshek-Schallhorn, Catherine B. Stroud, Leah Doane, Susan Mineka, Richard E. Zinbarg, Eva E. Redei, Michelle G. Craske, Emma K. Adam

    Research output: Contribution to journalArticle

    Abstract

    Background: The serotonin system and hypothalamic pituitary-adrenal (HPA)-axis are each implicated in the pathway to depression; human and animal research support these systems’ cross-talk. Our work implicates a 5-variant additive serotoninergic multilocus genetic profile score (MGPS) and separately the cortisol awakening response (CAR) in the prospective prediction of depression; other work has shown that the serotonin transporter polymorphism 5HTTLPR predicts CAR and interacts with the CAR to predict depression. Methods: We tested the hypothesis that a 6-variant MGPS (original plus 5HTTLPR) would interact with CAR to predict prospective depressive episode onsets in 201 emerging adults using four annual follow-up interviews. We also tested whether MGPS predicted CAR. We attempted replication of significant findings in a sample of 77 early adolescents predicting depression symptoms. Results: In sample 1, MGPS did not significantly predict CAR. MGPS interacted with CAR to predict depressive episodes; CAR slopes for depression steepened as MGPS increased, for risk or protection. No single variant accounted for results, though CAR’s interactions with 5HTTLPR and the original MGPS were both significant. In sample 2, the 6-variant MGPS significantly interacted with CAR to predict depression symptoms. Conclusions: Higher serotonergic MGPS appears to sensitize individuals to CAR level—for better and worse—in predicting depression.

    Original languageEnglish (US)
    JournalDepression and Anxiety
    DOIs
    StatePublished - Jan 1 2019

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    Hydrocortisone
    Research Personnel
    Pituitary-Adrenal System
    Serotonin Plasma Membrane Transport Proteins
    Serotonin
    Interviews

    Keywords

    • cortisol awakening response
    • depression
    • emerging adults
    • multilocus genetic profile score
    • serotonin

    ASJC Scopus subject areas

    • Clinical Psychology
    • Psychiatry and Mental health

    Cite this

    Cortisol awakening response and additive serotonergic genetic risk interactively predict depression in two samples : The 2019 Donald F. Klein Early Career Investigator Award Paper. / Vrshek-Schallhorn, Suzanne; Stroud, Catherine B.; Doane, Leah; Mineka, Susan; Zinbarg, Richard E.; Redei, Eva E.; Craske, Michelle G.; Adam, Emma K.

    In: Depression and Anxiety, 01.01.2019.

    Research output: Contribution to journalArticle

    Vrshek-Schallhorn, Suzanne ; Stroud, Catherine B. ; Doane, Leah ; Mineka, Susan ; Zinbarg, Richard E. ; Redei, Eva E. ; Craske, Michelle G. ; Adam, Emma K. / Cortisol awakening response and additive serotonergic genetic risk interactively predict depression in two samples : The 2019 Donald F. Klein Early Career Investigator Award Paper. In: Depression and Anxiety. 2019.
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    abstract = "Background: The serotonin system and hypothalamic pituitary-adrenal (HPA)-axis are each implicated in the pathway to depression; human and animal research support these systems’ cross-talk. Our work implicates a 5-variant additive serotoninergic multilocus genetic profile score (MGPS) and separately the cortisol awakening response (CAR) in the prospective prediction of depression; other work has shown that the serotonin transporter polymorphism 5HTTLPR predicts CAR and interacts with the CAR to predict depression. Methods: We tested the hypothesis that a 6-variant MGPS (original plus 5HTTLPR) would interact with CAR to predict prospective depressive episode onsets in 201 emerging adults using four annual follow-up interviews. We also tested whether MGPS predicted CAR. We attempted replication of significant findings in a sample of 77 early adolescents predicting depression symptoms. Results: In sample 1, MGPS did not significantly predict CAR. MGPS interacted with CAR to predict depressive episodes; CAR slopes for depression steepened as MGPS increased, for risk or protection. No single variant accounted for results, though CAR’s interactions with 5HTTLPR and the original MGPS were both significant. In sample 2, the 6-variant MGPS significantly interacted with CAR to predict depression symptoms. Conclusions: Higher serotonergic MGPS appears to sensitize individuals to CAR level—for better and worse—in predicting depression.",
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    AU - Stroud, Catherine B.

    AU - Doane, Leah

    AU - Mineka, Susan

    AU - Zinbarg, Richard E.

    AU - Redei, Eva E.

    AU - Craske, Michelle G.

    AU - Adam, Emma K.

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