Corticotropin-releasing hormone and cortisol: Longitudinal associations with depression and antisocial behavior in pregnant adolescents

Elizabeth J. Susman, Karen H. Schmeelk, Brenda K. Worrall, Douglas A. Granger, Angelo Ponirakis, George P. Chrousos

Research output: Contribution to journalArticlepeer-review

47 Scopus citations

Abstract

Objective: To examine the concurrent and longitudinal associations between corticotropin-releasing hormone (CRH) and cortisol concentrations and depression and antisocial behavior (conduct disorder symptoms) in pregnant adolescents. Method: Fifty-nine adolescents were evaluated in early pregnancy (9-21 weeks' gestation), late pregnancy (32-34 weeks' gestation), and the postpartum period (4-5 weeks postpartum). Symptoms of depression and conduct disorder were obtained from the Diagnostic Interview Schedule for Children. Results: Lower concentrations of CRH were related to a greater number of depression symptoms in early pregnancy (p < .05) and in late pregnancy (p < .05). Lower concentrations of CRH also were related to a greater number of conduct disorder symptoms in early pregnancy (p < .06) and in the postpartum period (p < .05). Conclusion: The findings support the long-standing hypothesis that stress-related products of the hypothalamic-pituitary- adrenal axis are associated with emotions and behavior during pregnancy.

Original languageEnglish (US)
Pages (from-to)460-467
Number of pages8
JournalJournal of the American Academy of Child and Adolescent Psychiatry
Volume38
Issue number4
DOIs
StatePublished - Jan 1 1999

Keywords

  • Conduct disorder
  • Corticotropin-releasing hormone
  • Depression
  • Pregnancy

ASJC Scopus subject areas

  • Developmental and Educational Psychology
  • Psychiatry and Mental health

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