Corticosterone rapidly suppresses innate immune activity in the house sparrow (Passer domesticus)

Sisi Gao, Clarissa Sanchez, Pierre Deviche

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Stress-induced effects on innate immune activity in wild birds have been difficult to predict. These difficulties may arise from the frequent assumptions that (1) the stress response influences different components of the immune response similarly, (2) stress-induced effects do not change over the course of the stress response and (3) glucocorticoids are the primary regulators of stress-induced changes of immune activity. We tested the first two assumptions by measuring three components of innate immunity at two times during the stress response in captive adult male house sparrows, Passer domesticus. Acute stress resulting from handling and restraint suppressed plasma lytic and microbicidal activity within 10 min and reduced plasma agglutination ability within 120 min. We tested the third assumption by measuring stress-induced effects in sparrows that were pharmacologically adrenalectomized by mitotane administration. Confirming the effectiveness of this treatment, mitotane-treated birds had lower pre-stress plasma CORT than control birds and showed no increase in plasma CORT during acute stress. The innate immune activity of mitotane-treated birds did not decrease during the stress response, but the pre-stress immune activity of these birds did not differ from that of vehicle-treated birds. These results suggest that elevated plasma CORT during stress is primarily responsible for mediating stress-induced suppression of innate immune activity.

Original languageEnglish (US)
Pages (from-to)322-327
Number of pages6
JournalJournal of Experimental Biology
Volume220
Issue number2
DOIs
StatePublished - Jan 15 2017

Fingerprint

Sparrows
Passer domesticus
mitotane
corticosterone
Corticosterone
Birds
stress response
Mitotane
birds
bird
plasma
Passeriformes
bird control
agglutination
wild birds
glucocorticoids
Agglutination
immune response
Innate Immunity
Glucocorticoids

Keywords

  • Glucocorticoid
  • Innate immunity
  • Mineralocorticoid receptor
  • Mitotane
  • Stress
  • Stress-induced immunosuppression

ASJC Scopus subject areas

  • Medicine(all)
  • Physiology
  • Ecology, Evolution, Behavior and Systematics
  • Aquatic Science
  • Molecular Biology
  • Animal Science and Zoology
  • Insect Science

Cite this

Corticosterone rapidly suppresses innate immune activity in the house sparrow (Passer domesticus). / Gao, Sisi; Sanchez, Clarissa; Deviche, Pierre.

In: Journal of Experimental Biology, Vol. 220, No. 2, 15.01.2017, p. 322-327.

Research output: Contribution to journalArticle

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