TY - JOUR
T1 - Cortical thickness and anxiety symptoms among cognitively normal elderly persons
T2 - The mayo clinic study of aging
AU - Pink, Anna
AU - Przybelski, Scott A.
AU - Krell-Roesch, Janina
AU - Stokin, Gorazd B.
AU - Roberts, Rosebud O.
AU - Mielke, Michelle M.
AU - Spangehl, Kathleen A.
AU - Knopman, David S.
AU - Jack, Clifford R.
AU - Petersen, Ronald C.
AU - Geda, Yonas E.
N1 - Publisher Copyright:
© 2017, American Psychiatric Association. All rights reserved.
PY - 2017
Y1 - 2017
N2 - The authors conducted a cross-sectional study to investigate the association between anxiety symptoms and cortical thickness, as well as amygdalar volume. A total of 1,505 cognitively normal participants, aged $70 years, were recruited from the Mayo Clinic Study of Aging in Olmsted County, Minnesota, on whom Beck Anxiety Inventory and 3T brain MRI data were available. Even though the effect sizes were small in this community-dwelling group of participants, anxiety symptoms were associated with reduced global cortical thickness and reduced thickness within the frontal and temporal cortex. However, after additionally adjusting for comorbid depressive symptoms, only the association between anxiety symptoms and reduced insular thickness remained significant.
AB - The authors conducted a cross-sectional study to investigate the association between anxiety symptoms and cortical thickness, as well as amygdalar volume. A total of 1,505 cognitively normal participants, aged $70 years, were recruited from the Mayo Clinic Study of Aging in Olmsted County, Minnesota, on whom Beck Anxiety Inventory and 3T brain MRI data were available. Even though the effect sizes were small in this community-dwelling group of participants, anxiety symptoms were associated with reduced global cortical thickness and reduced thickness within the frontal and temporal cortex. However, after additionally adjusting for comorbid depressive symptoms, only the association between anxiety symptoms and reduced insular thickness remained significant.
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U2 - 10.1176/appi.neuropsych.15100378
DO - 10.1176/appi.neuropsych.15100378
M3 - Article
C2 - 27578447
AN - SCOPUS:85012164049
SN - 0895-0172
VL - 29
SP - 60
EP - 66
JO - Journal of Neuropsychiatry and Clinical Neurosciences
JF - Journal of Neuropsychiatry and Clinical Neurosciences
IS - 1
ER -