Cortical reorganization in children with cochlear implants

Phillip M. Gilley; Anu Sharma; Michael Dorman

doi:10.1016/j.brainres.2008.08.026

Cortical reorganization in children with cochlear implants

Phillip M. Gilley, Anu Sharma, Michael Dorman

Biodesign Institute

Research output: Contribution to journal › Article › peer-review

130 Scopus citations

Abstract

Congenital deafness leads to atypical organization of the auditory nervous system. However, the extent to which auditory pathways reorganize during deafness is not well understood. We recorded cortical auditory evoked potentials in normal hearing children and in congenitally deaf children fitted with cochlear implants. High-density EEG and source modeling revealed principal activity from auditory cortex in normal hearing and early implanted children. However, children implanted after a critical period of seven years revealed activity from parietotemporal cortex in response to auditory stimulation, demonstrating reorganized cortical pathways. Reorganization of central auditory pathways is limited by the age at which implantation occurs, and may help explain the benefits and limitations of implantation in congenitally deaf children.

Original language	English (US)
Pages (from-to)	56-65
Number of pages	10
Journal	Brain Research
Volume	1239
DOIs	https://doi.org/10.1016/j.brainres.2008.08.026
State	Published - Nov 6 2008

Keywords

Auditory evoked potential
Critical period
Deafness
Development
Neuroplasticity
Source localization

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/j.brainres.2008.08.026

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title = "Cortical reorganization in children with cochlear implants",

abstract = "Congenital deafness leads to atypical organization of the auditory nervous system. However, the extent to which auditory pathways reorganize during deafness is not well understood. We recorded cortical auditory evoked potentials in normal hearing children and in congenitally deaf children fitted with cochlear implants. High-density EEG and source modeling revealed principal activity from auditory cortex in normal hearing and early implanted children. However, children implanted after a critical period of seven years revealed activity from parietotemporal cortex in response to auditory stimulation, demonstrating reorganized cortical pathways. Reorganization of central auditory pathways is limited by the age at which implantation occurs, and may help explain the benefits and limitations of implantation in congenitally deaf children.",

keywords = "Auditory evoked potential, Critical period, Deafness, Development, Neuroplasticity, Source localization",

author = "Gilley, {Phillip M.} and Anu Sharma and Michael Dorman",

note = "Funding Information: We would like to thank the two anonymous reviewers for their suggestions and expert opinion on this manuscript. We wish to thank the children and their families for their enthusiastic participation in this study, and to Kathryn Martin and Laura Veazey for their assistance in obtaining data for this study. We also wish to acknowledge the input of Aage M{\o}ller, James Jerger, and Teresa Mitchell while preparing this manuscript. This research was supported by funding from the National Institutes of Health (NIH-NIDCD R01-DC004552 and NIH-NIDCD R01-DC006257) to author AS.",

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doi = "10.1016/j.brainres.2008.08.026",

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T1 - Cortical reorganization in children with cochlear implants

AU - Gilley, Phillip M.

AU - Sharma, Anu

AU - Dorman, Michael

N1 - Funding Information: We would like to thank the two anonymous reviewers for their suggestions and expert opinion on this manuscript. We wish to thank the children and their families for their enthusiastic participation in this study, and to Kathryn Martin and Laura Veazey for their assistance in obtaining data for this study. We also wish to acknowledge the input of Aage Møller, James Jerger, and Teresa Mitchell while preparing this manuscript. This research was supported by funding from the National Institutes of Health (NIH-NIDCD R01-DC004552 and NIH-NIDCD R01-DC006257) to author AS.

PY - 2008/11/6

Y1 - 2008/11/6

N2 - Congenital deafness leads to atypical organization of the auditory nervous system. However, the extent to which auditory pathways reorganize during deafness is not well understood. We recorded cortical auditory evoked potentials in normal hearing children and in congenitally deaf children fitted with cochlear implants. High-density EEG and source modeling revealed principal activity from auditory cortex in normal hearing and early implanted children. However, children implanted after a critical period of seven years revealed activity from parietotemporal cortex in response to auditory stimulation, demonstrating reorganized cortical pathways. Reorganization of central auditory pathways is limited by the age at which implantation occurs, and may help explain the benefits and limitations of implantation in congenitally deaf children.

AB - Congenital deafness leads to atypical organization of the auditory nervous system. However, the extent to which auditory pathways reorganize during deafness is not well understood. We recorded cortical auditory evoked potentials in normal hearing children and in congenitally deaf children fitted with cochlear implants. High-density EEG and source modeling revealed principal activity from auditory cortex in normal hearing and early implanted children. However, children implanted after a critical period of seven years revealed activity from parietotemporal cortex in response to auditory stimulation, demonstrating reorganized cortical pathways. Reorganization of central auditory pathways is limited by the age at which implantation occurs, and may help explain the benefits and limitations of implantation in congenitally deaf children.

KW - Auditory evoked potential

KW - Critical period

KW - Deafness

KW - Development

KW - Neuroplasticity

KW - Source localization

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VL - 1239

SP - 56

EP - 65

JO - Brain Research

JF - Brain Research

ER -

Cortical reorganization in children with cochlear implants

Abstract

Keywords

ASJC Scopus subject areas

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