Corrigendum to “Anti-α-synuclein ASO delivered to monoamine neurons prevents α-synuclein accumulation in a Parkinson's disease-like mouse model and in monkeys” (EBioMedicine (2020) 59, (S2352396420303200), (10.1016/j.ebiom.2020.102944))

Diana Alarcón-Arís, Rubén Pavia-Collado, Lluis Miquel-Rio, Valentín Coppola-Segovia, Albert Ferrés-Coy, Esther Ruiz-Bronchal, Mireia Galofré, Verónica Paz, Leticia Campa, Raquel Revilla, Andrés Montefeltro, Jeffrey H. Kordower, Miquel Vila, Francesc Artigas, Analia Bortolozzi

Research output: Contribution to journalComment/debatepeer-review

Abstract

The authors have recently noticed that the published version of this article contained errors in the accession code and in the antisense oligonucleotide sequence for detecting human α-synuclein mRNA using in situ hybridization. The correct sequence complementary to bases 669-709 corresponds to GenBank accession https://www.ncbi.nlm.nih.gov/nuccore/NM_000345.4. Moreover, unlike IND-1233-ASO, the IND-1337-ASO sequence is not 100% complementary to human α-synuclein mRNA. IND-1337-ASO sequence was optimized for the AAV5-CBA construct that encodes the human-α-synuclein provided by Michael J. Fox Foundation. The sequence was modified to fully match that inserted in this model including mouse codon optimization. These corrections do not change the description, interpretation, or the original conclusions of the manuscript. The authors apologize for any inconvenience caused by these unintentional errors.

Original languageEnglish (US)
Article number103731
JournalEBioMedicine
Volume74
DOIs
StatePublished - Dec 2021
Externally publishedYes

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology

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