Corpus Callosum Structural Integrity Is Associated with Postural Control Improvement in Persons with Multiple Sclerosis Who Have Minimal Disability

Daniel Peterson, Geetanjali Gera, Fay B. Horak, Brett W. Fling

    Research output: Contribution to journalArticle

    7 Citations (Scopus)

    Abstract

    Background. Improvement of postural control in persons with multiple sclerosis (PwMS) is an important target for neurorehabilitation. Although PwMS are able to improve postural performance with training, the neural underpinnings of these improvements are poorly understood. Objective. To understand the neural underpinnings of postural motor learning in PwMS. Methods. Supraspinal white matter structural connectivity in PwMS was correlated with improvements in postural performance (balancing on an oscillating surface over 25 trials) and retention of improvements (24 hours later). Results. Improvement in postural performance was directly correlated to microstructural integrity of white matter tracts, measured as radial diffusivity, in the corpus callosum, posterior parieto-sensorimotor fibers and the brainstem in PwMS. Within the corpus callosum, the genu and midbody (fibers connecting the prefrontal and primary motor cortices, respectively) were most strongly correlated to improvements in postural control. Twenty-four-hour retention was not correlated to radial diffusivity. Conclusion. PwMS who exhibited poorer white matter tract integrity connecting the cortical hemispheres via the corpus callosum showed the most difficulty learning to control balance on an unstable surface. Prediction of improvements in postural control through training (ie, motor learning) via structural imaging of the brain may allow for identification of individuals who are particularly well suited for postural rehabilitation interventions.

    Original languageEnglish (US)
    Pages (from-to)343-353
    Number of pages11
    JournalNeurorehabilitation and Neural Repair
    Volume31
    Issue number4
    DOIs
    StatePublished - Apr 1 2017

    Fingerprint

    Corpus Callosum
    Multiple Sclerosis
    Learning
    Motor Cortex
    Neuroimaging
    Brain Stem
    Rehabilitation
    White Matter

    Keywords

    • balance
    • diffusion tensor imaging
    • motor learning
    • multiple sclerosis
    • posture
    • white matter

    ASJC Scopus subject areas

    • Rehabilitation
    • Neurology
    • Clinical Neurology

    Cite this

    Corpus Callosum Structural Integrity Is Associated with Postural Control Improvement in Persons with Multiple Sclerosis Who Have Minimal Disability. / Peterson, Daniel; Gera, Geetanjali; Horak, Fay B.; Fling, Brett W.

    In: Neurorehabilitation and Neural Repair, Vol. 31, No. 4, 01.04.2017, p. 343-353.

    Research output: Contribution to journalArticle

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    abstract = "Background. Improvement of postural control in persons with multiple sclerosis (PwMS) is an important target for neurorehabilitation. Although PwMS are able to improve postural performance with training, the neural underpinnings of these improvements are poorly understood. Objective. To understand the neural underpinnings of postural motor learning in PwMS. Methods. Supraspinal white matter structural connectivity in PwMS was correlated with improvements in postural performance (balancing on an oscillating surface over 25 trials) and retention of improvements (24 hours later). Results. Improvement in postural performance was directly correlated to microstructural integrity of white matter tracts, measured as radial diffusivity, in the corpus callosum, posterior parieto-sensorimotor fibers and the brainstem in PwMS. Within the corpus callosum, the genu and midbody (fibers connecting the prefrontal and primary motor cortices, respectively) were most strongly correlated to improvements in postural control. Twenty-four-hour retention was not correlated to radial diffusivity. Conclusion. PwMS who exhibited poorer white matter tract integrity connecting the cortical hemispheres via the corpus callosum showed the most difficulty learning to control balance on an unstable surface. Prediction of improvements in postural control through training (ie, motor learning) via structural imaging of the brain may allow for identification of individuals who are particularly well suited for postural rehabilitation interventions.",
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