Cord serum concentrations of perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) in relation to weight and size at birth

Benjamin J. Apelberg, Frank R. Witter, Julie B. Herbstman, Antonia M. Calafat, Rolf Halden, Larry L. Needham, Lynn R. Goldman

Research output: Contribution to journalArticle

361 Citations (Scopus)

Abstract

BACKGROUND: Recent studies have reported developmental toxicity among rodents dosed with perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA). OBJECTIVES: We examined the relationship between concentrations of PFOS and PFOA in cord serum (surrogates for in utero exposures) and gestational age, birth weight, and birth size in humans. METHODS: We conducted a hospital-based cross-sectional epidemiologic study of singleton deliveries in Baltimore, Maryland. Cord serum samples (n = 293) were analyzed for PFOS and PFOA by online solid-phase extraction, coupled with reversed-phase high-performance liquid chromatography-isotope dilution tandem mass spectrometry. Maternal characteristics and anthropometric measures were obtained from medical charts. RESULTS: After adjusting for potential confounders, both PFOS and PFOA were negatively associated with birth weight [per ln-unit: β = -69 g, 95% confidence interval (CI), -149 to 10 for PFOS; β= -104 g, 95% CI, -213 to 5 for PFOA], ponderal index (per ln-unit: β = -0.074 g/cm3 × 100, 95% CI, -0.123 to -0.025 for PFOS; β = -0.070 g/cm3 × 100, 95% CI, -0.138 to -0.001 for PFOA), and head circumference (per ln-unit: β = -0.32 cm, 95% CI, -0.56 to -0.07 for PFOS; β = -0.41 cm, 95% CI, -0.76 to -0.07 for PFOA). No associations were observed between either PFOS or PFOA concentrations and newborn length or gestational age. All associations were independent of cord serum lipid concentrations. CONCLUSIONS: Despite relatively low cord serum concentrations, we observed small negative associations between both PFOS and PFOA concentrations and birth weight and size. Future studies should attempt to replicate these findings in other populations.

Original languageEnglish (US)
Pages (from-to)1670-1676
Number of pages7
JournalEnvironmental Health Perspectives
Volume115
Issue number11
DOIs
StatePublished - Nov 2007
Externally publishedYes

Fingerprint

perfluorooctanoic acid
sulfonate
serum
Parturition
Weights and Measures
confidence interval
Serum
Confidence Intervals
Birth Weight
Gestational Age
perfluorooctane sulfonic acid
Baltimore
Solid Phase Extraction

Keywords

  • Birth weight
  • Cord blood
  • Epidemiology
  • Fetal exposure
  • Fetal growth
  • Gestational age
  • Head circumference
  • Human
  • Length
  • Perfluorooctane sulfonate
  • Perfluorooctanoate
  • Polyfluoroalkyl compounds
  • Ponderal index

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Public Health, Environmental and Occupational Health
  • Environmental Science(all)
  • Environmental Chemistry

Cite this

Cord serum concentrations of perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) in relation to weight and size at birth. / Apelberg, Benjamin J.; Witter, Frank R.; Herbstman, Julie B.; Calafat, Antonia M.; Halden, Rolf; Needham, Larry L.; Goldman, Lynn R.

In: Environmental Health Perspectives, Vol. 115, No. 11, 11.2007, p. 1670-1676.

Research output: Contribution to journalArticle

Apelberg, Benjamin J. ; Witter, Frank R. ; Herbstman, Julie B. ; Calafat, Antonia M. ; Halden, Rolf ; Needham, Larry L. ; Goldman, Lynn R. / Cord serum concentrations of perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) in relation to weight and size at birth. In: Environmental Health Perspectives. 2007 ; Vol. 115, No. 11. pp. 1670-1676.
@article{f15cdfdd72c848a0a9421a583756b5aa,
title = "Cord serum concentrations of perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) in relation to weight and size at birth",
abstract = "BACKGROUND: Recent studies have reported developmental toxicity among rodents dosed with perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA). OBJECTIVES: We examined the relationship between concentrations of PFOS and PFOA in cord serum (surrogates for in utero exposures) and gestational age, birth weight, and birth size in humans. METHODS: We conducted a hospital-based cross-sectional epidemiologic study of singleton deliveries in Baltimore, Maryland. Cord serum samples (n = 293) were analyzed for PFOS and PFOA by online solid-phase extraction, coupled with reversed-phase high-performance liquid chromatography-isotope dilution tandem mass spectrometry. Maternal characteristics and anthropometric measures were obtained from medical charts. RESULTS: After adjusting for potential confounders, both PFOS and PFOA were negatively associated with birth weight [per ln-unit: β = -69 g, 95{\%} confidence interval (CI), -149 to 10 for PFOS; β= -104 g, 95{\%} CI, -213 to 5 for PFOA], ponderal index (per ln-unit: β = -0.074 g/cm3 × 100, 95{\%} CI, -0.123 to -0.025 for PFOS; β = -0.070 g/cm3 × 100, 95{\%} CI, -0.138 to -0.001 for PFOA), and head circumference (per ln-unit: β = -0.32 cm, 95{\%} CI, -0.56 to -0.07 for PFOS; β = -0.41 cm, 95{\%} CI, -0.76 to -0.07 for PFOA). No associations were observed between either PFOS or PFOA concentrations and newborn length or gestational age. All associations were independent of cord serum lipid concentrations. CONCLUSIONS: Despite relatively low cord serum concentrations, we observed small negative associations between both PFOS and PFOA concentrations and birth weight and size. Future studies should attempt to replicate these findings in other populations.",
keywords = "Birth weight, Cord blood, Epidemiology, Fetal exposure, Fetal growth, Gestational age, Head circumference, Human, Length, Perfluorooctane sulfonate, Perfluorooctanoate, Polyfluoroalkyl compounds, Ponderal index",
author = "Apelberg, {Benjamin J.} and Witter, {Frank R.} and Herbstman, {Julie B.} and Calafat, {Antonia M.} and Rolf Halden and Needham, {Larry L.} and Goldman, {Lynn R.}",
year = "2007",
month = "11",
doi = "10.1289/ehp.10334",
language = "English (US)",
volume = "115",
pages = "1670--1676",
journal = "Environmental Health Perspectives",
issn = "0091-6765",
publisher = "Public Health Services, US Dept of Health and Human Services",
number = "11",

}

TY - JOUR

T1 - Cord serum concentrations of perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) in relation to weight and size at birth

AU - Apelberg, Benjamin J.

AU - Witter, Frank R.

AU - Herbstman, Julie B.

AU - Calafat, Antonia M.

AU - Halden, Rolf

AU - Needham, Larry L.

AU - Goldman, Lynn R.

PY - 2007/11

Y1 - 2007/11

N2 - BACKGROUND: Recent studies have reported developmental toxicity among rodents dosed with perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA). OBJECTIVES: We examined the relationship between concentrations of PFOS and PFOA in cord serum (surrogates for in utero exposures) and gestational age, birth weight, and birth size in humans. METHODS: We conducted a hospital-based cross-sectional epidemiologic study of singleton deliveries in Baltimore, Maryland. Cord serum samples (n = 293) were analyzed for PFOS and PFOA by online solid-phase extraction, coupled with reversed-phase high-performance liquid chromatography-isotope dilution tandem mass spectrometry. Maternal characteristics and anthropometric measures were obtained from medical charts. RESULTS: After adjusting for potential confounders, both PFOS and PFOA were negatively associated with birth weight [per ln-unit: β = -69 g, 95% confidence interval (CI), -149 to 10 for PFOS; β= -104 g, 95% CI, -213 to 5 for PFOA], ponderal index (per ln-unit: β = -0.074 g/cm3 × 100, 95% CI, -0.123 to -0.025 for PFOS; β = -0.070 g/cm3 × 100, 95% CI, -0.138 to -0.001 for PFOA), and head circumference (per ln-unit: β = -0.32 cm, 95% CI, -0.56 to -0.07 for PFOS; β = -0.41 cm, 95% CI, -0.76 to -0.07 for PFOA). No associations were observed between either PFOS or PFOA concentrations and newborn length or gestational age. All associations were independent of cord serum lipid concentrations. CONCLUSIONS: Despite relatively low cord serum concentrations, we observed small negative associations between both PFOS and PFOA concentrations and birth weight and size. Future studies should attempt to replicate these findings in other populations.

AB - BACKGROUND: Recent studies have reported developmental toxicity among rodents dosed with perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA). OBJECTIVES: We examined the relationship between concentrations of PFOS and PFOA in cord serum (surrogates for in utero exposures) and gestational age, birth weight, and birth size in humans. METHODS: We conducted a hospital-based cross-sectional epidemiologic study of singleton deliveries in Baltimore, Maryland. Cord serum samples (n = 293) were analyzed for PFOS and PFOA by online solid-phase extraction, coupled with reversed-phase high-performance liquid chromatography-isotope dilution tandem mass spectrometry. Maternal characteristics and anthropometric measures were obtained from medical charts. RESULTS: After adjusting for potential confounders, both PFOS and PFOA were negatively associated with birth weight [per ln-unit: β = -69 g, 95% confidence interval (CI), -149 to 10 for PFOS; β= -104 g, 95% CI, -213 to 5 for PFOA], ponderal index (per ln-unit: β = -0.074 g/cm3 × 100, 95% CI, -0.123 to -0.025 for PFOS; β = -0.070 g/cm3 × 100, 95% CI, -0.138 to -0.001 for PFOA), and head circumference (per ln-unit: β = -0.32 cm, 95% CI, -0.56 to -0.07 for PFOS; β = -0.41 cm, 95% CI, -0.76 to -0.07 for PFOA). No associations were observed between either PFOS or PFOA concentrations and newborn length or gestational age. All associations were independent of cord serum lipid concentrations. CONCLUSIONS: Despite relatively low cord serum concentrations, we observed small negative associations between both PFOS and PFOA concentrations and birth weight and size. Future studies should attempt to replicate these findings in other populations.

KW - Birth weight

KW - Cord blood

KW - Epidemiology

KW - Fetal exposure

KW - Fetal growth

KW - Gestational age

KW - Head circumference

KW - Human

KW - Length

KW - Perfluorooctane sulfonate

KW - Perfluorooctanoate

KW - Polyfluoroalkyl compounds

KW - Ponderal index

UR - http://www.scopus.com/inward/record.url?scp=38449100087&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=38449100087&partnerID=8YFLogxK

U2 - 10.1289/ehp.10334

DO - 10.1289/ehp.10334

M3 - Article

C2 - 18008002

AN - SCOPUS:38449100087

VL - 115

SP - 1670

EP - 1676

JO - Environmental Health Perspectives

JF - Environmental Health Perspectives

SN - 0091-6765

IS - 11

ER -