Copper(I)-bleomycin. A structurally unique oxidation-reduction active complex

N. J. Oppenheimer, C. Chang, L. O. Rodriguez, S. M. Hecht

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

Cu(I) and Cu(II) form stable 1:1 complexes with bleomycin (BLM). The affinity of both metals for the drug is greater than that of Fe(II). Cu(I)-BLM A2 binds to calf thymus DNA with about the same affinity as Fe(II)-BLM, as judged by DNA-induced fluorescence quenching of the bithiazole moiety of BLM. Based on 1H NMR and potentiometric titration data, the Cu(I) complexes of BLM are shown to have geometries very different than those of other BLM-metal(II) complexes studied thus far. As Cu(I)-BLM is oxidation-reduction active, its geometry is of importance in defining the structural requirements for BLM activity.

Original languageEnglish (US)
Pages (from-to)1514-1517
Number of pages4
JournalJournal of Biological Chemistry
Volume256
Issue number4
StatePublished - Jan 1 1981
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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