Copolymers of N-isopropylacrylamide HEMA-lactate and acrylic acid with time-dependent lower critical solution temperature as a bioresorbable carrier

Bae Hoon Lee, Brent Vernon

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Copolymers of N-isopropylacrylamide (NIPAAm), 2-hydroxyethyl methacryl lactate (HEMA-lactate) and acrylic acid (AAc) were prepared, with varying mole ratios of monomers, to develop a bioresorbable in-situ-gelling material with a time-dependent lower critical solution temperature (LCST). The synthesized copolymers were characterized by nuclear magnetic resonance, gel permeation chromatography and differential scanning calorimetry. In 0.1 M phosphate-buffered saline solution of pH 7.4, these copolymers had an LCST below body temperature. The LCST decreased as the HEMA-lactate content of the copolymers was increased. Furthermore, in these conditions, the LCST of the copolymers exhibited time-dependent properties, due to hydrolysis of the HEMA-lactate. As the HEMA-lactate hydrolyzed, the copolymers became more hydrophilic, thereby leading to an increase in LCST. This hydrophilicity caused copolymers of approximately 6 mol% of AAc to exhibit an LCST above body temperature after hydrolysis. In neutral solution, copolymers with varying mol% of AAc saw their LCST rise above 37°C within one to ten days, depending upon the HEMA-lactate/NIPAAm ratio, due to the complete hydrolysis of the HEMA-lactate. The above properties indicate that these copolymers would be useful for drug delivery because their variable LCST makes them bioresorbable.

Original languageEnglish (US)
Pages (from-to)418-422
Number of pages5
JournalPolymer International
Volume54
Issue number2
DOIs
StatePublished - Feb 2005

Fingerprint

Acrylics
Lactic Acid
Copolymers
Acids
Temperature
Hydrolysis
N-isopropylacrylamide
acrylic acid
Hydrophilicity
Gel permeation chromatography
Drug delivery
Sodium Chloride
Differential scanning calorimetry
Phosphates
Monomers
Nuclear magnetic resonance

Keywords

  • Acrylic acid
  • Bioresorbable
  • Hydrolysis
  • LCST
  • Thermosensitive polymer

ASJC Scopus subject areas

  • Polymers and Plastics

Cite this

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title = "Copolymers of N-isopropylacrylamide HEMA-lactate and acrylic acid with time-dependent lower critical solution temperature as a bioresorbable carrier",
abstract = "Copolymers of N-isopropylacrylamide (NIPAAm), 2-hydroxyethyl methacryl lactate (HEMA-lactate) and acrylic acid (AAc) were prepared, with varying mole ratios of monomers, to develop a bioresorbable in-situ-gelling material with a time-dependent lower critical solution temperature (LCST). The synthesized copolymers were characterized by nuclear magnetic resonance, gel permeation chromatography and differential scanning calorimetry. In 0.1 M phosphate-buffered saline solution of pH 7.4, these copolymers had an LCST below body temperature. The LCST decreased as the HEMA-lactate content of the copolymers was increased. Furthermore, in these conditions, the LCST of the copolymers exhibited time-dependent properties, due to hydrolysis of the HEMA-lactate. As the HEMA-lactate hydrolyzed, the copolymers became more hydrophilic, thereby leading to an increase in LCST. This hydrophilicity caused copolymers of approximately 6 mol{\%} of AAc to exhibit an LCST above body temperature after hydrolysis. In neutral solution, copolymers with varying mol{\%} of AAc saw their LCST rise above 37°C within one to ten days, depending upon the HEMA-lactate/NIPAAm ratio, due to the complete hydrolysis of the HEMA-lactate. The above properties indicate that these copolymers would be useful for drug delivery because their variable LCST makes them bioresorbable.",
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author = "Lee, {Bae Hoon} and Brent Vernon",
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AU - Vernon, Brent

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N2 - Copolymers of N-isopropylacrylamide (NIPAAm), 2-hydroxyethyl methacryl lactate (HEMA-lactate) and acrylic acid (AAc) were prepared, with varying mole ratios of monomers, to develop a bioresorbable in-situ-gelling material with a time-dependent lower critical solution temperature (LCST). The synthesized copolymers were characterized by nuclear magnetic resonance, gel permeation chromatography and differential scanning calorimetry. In 0.1 M phosphate-buffered saline solution of pH 7.4, these copolymers had an LCST below body temperature. The LCST decreased as the HEMA-lactate content of the copolymers was increased. Furthermore, in these conditions, the LCST of the copolymers exhibited time-dependent properties, due to hydrolysis of the HEMA-lactate. As the HEMA-lactate hydrolyzed, the copolymers became more hydrophilic, thereby leading to an increase in LCST. This hydrophilicity caused copolymers of approximately 6 mol% of AAc to exhibit an LCST above body temperature after hydrolysis. In neutral solution, copolymers with varying mol% of AAc saw their LCST rise above 37°C within one to ten days, depending upon the HEMA-lactate/NIPAAm ratio, due to the complete hydrolysis of the HEMA-lactate. The above properties indicate that these copolymers would be useful for drug delivery because their variable LCST makes them bioresorbable.

AB - Copolymers of N-isopropylacrylamide (NIPAAm), 2-hydroxyethyl methacryl lactate (HEMA-lactate) and acrylic acid (AAc) were prepared, with varying mole ratios of monomers, to develop a bioresorbable in-situ-gelling material with a time-dependent lower critical solution temperature (LCST). The synthesized copolymers were characterized by nuclear magnetic resonance, gel permeation chromatography and differential scanning calorimetry. In 0.1 M phosphate-buffered saline solution of pH 7.4, these copolymers had an LCST below body temperature. The LCST decreased as the HEMA-lactate content of the copolymers was increased. Furthermore, in these conditions, the LCST of the copolymers exhibited time-dependent properties, due to hydrolysis of the HEMA-lactate. As the HEMA-lactate hydrolyzed, the copolymers became more hydrophilic, thereby leading to an increase in LCST. This hydrophilicity caused copolymers of approximately 6 mol% of AAc to exhibit an LCST above body temperature after hydrolysis. In neutral solution, copolymers with varying mol% of AAc saw their LCST rise above 37°C within one to ten days, depending upon the HEMA-lactate/NIPAAm ratio, due to the complete hydrolysis of the HEMA-lactate. The above properties indicate that these copolymers would be useful for drug delivery because their variable LCST makes them bioresorbable.

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