Abstract
Recent approaches to stress regulation have emphasized coordination among multiple biological systems. This study builds on evidence that hypothalamic-pituitary-adrenal (HPA) axis activity should be considered in coordination with other stress-sensitive biological systems to characterize healthy responses. Healthy African-Americans (n = 115) completed the Trier Social Stress Test, and biological responses were assessed through salivary cortisol, dehydroepiandrosterone-sulfate (DHEA-S), alpha amylase (sAA), and C-reactive protein (sCRP). Multilevel modeling demonstrated that cortisol responses typically aligned with changes in DHEA-S, sAA, and sCRP across the session. At the same time, the degree of cortisol coordination with sAA and sCRP varied by participants' subjective stress following the task; participants with higher secondary stress appraisals showed greater cortisol-sAA alignment, whereas those experiencing more negative affect showed greater cortisol-sCRP alignment. Results highlight the importance of a multisystem approach to stress and suggest that positive HPA axis coordination with the autonomic response, but not with the immune/inflammatory response, may be adaptive.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 17-24 |
| Number of pages | 8 |
| Journal | Biological Psychology |
| Volume | 118 |
| DOIs | |
| State | Published - Jul 1 2016 |
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Keywords
- Alpha-amylase
- C-reactive protein
- Coordination
- Cortisol
- DHEA-S
- Stress
- Trier Social Stress Test
ASJC Scopus subject areas
- Neuroscience(all)
- Neuropsychology and Physiological Psychology
Cite this
Coordination of cortisol response to social evaluative threat with autonomic and inflammatory responses is moderated by stress appraisals and affect. / Laurent, Heidemarie K.; Lucas, Todd; Pierce, Jennifer; Goetz, Stefan; Granger, Douglas A.
In: Biological Psychology, Vol. 118, 01.07.2016, p. 17-24.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Coordination of cortisol response to social evaluative threat with autonomic and inflammatory responses is moderated by stress appraisals and affect
AU - Laurent, Heidemarie K.
AU - Lucas, Todd
AU - Pierce, Jennifer
AU - Goetz, Stefan
AU - Granger, Douglas A.
PY - 2016/7/1
Y1 - 2016/7/1
N2 - Recent approaches to stress regulation have emphasized coordination among multiple biological systems. This study builds on evidence that hypothalamic-pituitary-adrenal (HPA) axis activity should be considered in coordination with other stress-sensitive biological systems to characterize healthy responses. Healthy African-Americans (n = 115) completed the Trier Social Stress Test, and biological responses were assessed through salivary cortisol, dehydroepiandrosterone-sulfate (DHEA-S), alpha amylase (sAA), and C-reactive protein (sCRP). Multilevel modeling demonstrated that cortisol responses typically aligned with changes in DHEA-S, sAA, and sCRP across the session. At the same time, the degree of cortisol coordination with sAA and sCRP varied by participants' subjective stress following the task; participants with higher secondary stress appraisals showed greater cortisol-sAA alignment, whereas those experiencing more negative affect showed greater cortisol-sCRP alignment. Results highlight the importance of a multisystem approach to stress and suggest that positive HPA axis coordination with the autonomic response, but not with the immune/inflammatory response, may be adaptive.
AB - Recent approaches to stress regulation have emphasized coordination among multiple biological systems. This study builds on evidence that hypothalamic-pituitary-adrenal (HPA) axis activity should be considered in coordination with other stress-sensitive biological systems to characterize healthy responses. Healthy African-Americans (n = 115) completed the Trier Social Stress Test, and biological responses were assessed through salivary cortisol, dehydroepiandrosterone-sulfate (DHEA-S), alpha amylase (sAA), and C-reactive protein (sCRP). Multilevel modeling demonstrated that cortisol responses typically aligned with changes in DHEA-S, sAA, and sCRP across the session. At the same time, the degree of cortisol coordination with sAA and sCRP varied by participants' subjective stress following the task; participants with higher secondary stress appraisals showed greater cortisol-sAA alignment, whereas those experiencing more negative affect showed greater cortisol-sCRP alignment. Results highlight the importance of a multisystem approach to stress and suggest that positive HPA axis coordination with the autonomic response, but not with the immune/inflammatory response, may be adaptive.
KW - Alpha-amylase
KW - C-reactive protein
KW - Coordination
KW - Cortisol
KW - DHEA-S
KW - Stress
KW - Trier Social Stress Test
UR - http://www.scopus.com/inward/record.url?scp=84965034925&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84965034925&partnerID=8YFLogxK
U2 - 10.1016/j.biopsycho.2016.04.066
DO - 10.1016/j.biopsycho.2016.04.066
M3 - Article
AN - SCOPUS:84965034925
VL - 118
SP - 17
EP - 24
JO - Biological Psychology
JF - Biological Psychology
SN - 0019-493X
ER -