Coordinating the impact of structural genomics on the human α-helical transmembrane proteome

Ursula Pieper; Avner Schlessinger; Edda Kloppmann; Geoffrey A. Chang; James J. Chou; Mark E. Dumont; Brian G. Fox; Petra Fromme; Wayne A. Hendrickson; Michael G. Malkowski; Douglas C. Rees; David L. Stokes; Michael H B Stowell; Michael C. Wiener; Burkhard Rost; Robert M. Stroud; Raymond C. Stevens; Andrej Sali

doi:10.1038/nsmb.2508

Coordinating the impact of structural genomics on the human α-helical transmembrane proteome

Ursula Pieper, Avner Schlessinger, Edda Kloppmann, Geoffrey A. Chang, James J. Chou, Mark E. Dumont, Brian G. Fox, Petra Fromme, Wayne A. Hendrickson, Michael G. Malkowski, Douglas C. Rees, David L. Stokes, Michael H B Stowell, Michael C. Wiener, Burkhard Rost, Robert M. Stroud, Raymond C. Stevens, Andrej Sali

Research output: Contribution to journal › Review article › peer-review

55 Scopus citations

Abstract

Given the recent successes in determining membrane-protein structures, we explore the tractability of determining representatives for the entire human membrane proteome. This proteome contains 2,925 unique integral α-helical transmembrane-domain sequences that cluster into 1,201 families sharing more than 25% sequence identity. Structures of 100 optimally selected targets would increase the fraction of modelable human α-helical transmembrane domains from 26% to 58%, providing structure and function information not otherwise available.

Original language	English (US)
Pages (from-to)	135-138
Number of pages	4
Journal	Nature Structural and Molecular Biology
Volume	20
Issue number	2
DOIs	https://doi.org/10.1038/nsmb.2508
State	Published - Feb 2013

ASJC Scopus subject areas

Structural Biology
Molecular Biology

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10.1038/nsmb.2508

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Pieper, U., Schlessinger, A., Kloppmann, E., Chang, G. A., Chou, J. J., Dumont, M. E., Fox, B. G., Fromme, P., Hendrickson, W. A., Malkowski, M. G., Rees, D. C., Stokes, D. L., Stowell, M. H. B., Wiener, M. C., Rost, B., Stroud, R. M., Stevens, R. C., & Sali, A. (2013). Coordinating the impact of structural genomics on the human α-helical transmembrane proteome. Nature Structural and Molecular Biology, 20(2), 135-138. https://doi.org/10.1038/nsmb.2508

Pieper, U, Schlessinger, A, Kloppmann, E, Chang, GA, Chou, JJ, Dumont, ME, Fox, BG, Fromme, P, Hendrickson, WA, Malkowski, MG, Rees, DC, Stokes, DL, Stowell, MHB, Wiener, MC, Rost, B, Stroud, RM, Stevens, RC & Sali, A 2013, 'Coordinating the impact of structural genomics on the human α-helical transmembrane proteome', Nature Structural and Molecular Biology, vol. 20, no. 2, pp. 135-138. https://doi.org/10.1038/nsmb.2508

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AU - Rees, Douglas C.

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AU - Sali, Andrej

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Coordinating the impact of structural genomics on the human α-helical transmembrane proteome

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