Controlling the motion of DNA in a nanochannel with transversal alternating electric voltages

Binquan Luan, Chao Wang, Ajay Royyuru, Gustavo Stolovitzky

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

A nanofluidic channel, with a pair of perpendicularly aligned nanoelectrodes, is proposed to electrically control the motion of DNA molecules. Using all-atom molecular dynamics simulations, we studied electrostatic responses of a charged DNA molecule in the nanochannel and investigated optimized operating conditions for controlling the DNA molecule. When the transversal electric field was periodically turned on and off, the DNA molecule was correspondingly immobilized on and released from the channel surface. Under simultaneously applied longitudinal biasing and transversal trapping electric fields, the DNA molecule moved forward in a 'ratchet'-like fashion. It is expected that achieving the controlled motion of DNA in the channel can advance studies and applications of a nanochannel-based sensor for analyzing DNA (e.g., DNA sequencing).

Original languageEnglish (US)
Article number265101
JournalNanotechnology
Volume25
Issue number26
DOIs
StatePublished - Jul 4 2014
Externally publishedYes

Fingerprint

DNA
Electric potential
Molecules
Electric fields
Nanofluidics
Molecular Dynamics Simulation
Static Electricity
DNA Sequence Analysis
Molecular dynamics
Electrostatics
Atoms
Sensors
Computer simulation

Keywords

  • DNA
  • nanochannel
  • ratcheting

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Electrical and Electronic Engineering
  • Mechanical Engineering
  • Mechanics of Materials
  • Materials Science(all)
  • Medicine(all)

Cite this

Controlling the motion of DNA in a nanochannel with transversal alternating electric voltages. / Luan, Binquan; Wang, Chao; Royyuru, Ajay; Stolovitzky, Gustavo.

In: Nanotechnology, Vol. 25, No. 26, 265101, 04.07.2014.

Research output: Contribution to journalArticle

Luan, Binquan ; Wang, Chao ; Royyuru, Ajay ; Stolovitzky, Gustavo. / Controlling the motion of DNA in a nanochannel with transversal alternating electric voltages. In: Nanotechnology. 2014 ; Vol. 25, No. 26.
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