Controlling fiber alignment using magnetically-assisted electrospinning for interfacial tissue repair

R. Kevin Tindell, Julianne Holloway

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Statement of Purpose: Although there have been significant advances within tissue engineering, translation has proven difficult with ongoing challenges regenerating complex tissues with a heterogeneous structure and multiple cell types. In particular, the transitional or interfacial tissue between adjacent tissues has complex gradients of structure, cell type, and chemical composition. For example, the tendon to bone interfacial tissue gradually transitions from highly aligned fibrous tissue to calcified bone [1]. For transitions between musculoskeletal tissues (e.g., ligament or tendon to bone, muscle to tendon, cartilage to bone, etc.), the interfacial region is critical for transferring mechanical load from one tissue type to another. Developing new biomaterial fabrication strategies capable of mimicking the heterogeneous nature of interfacial tissues, as well as other complex tissues, is vital for spatially controlling cellular behavior and resulting in functional interfacial tissue regeneration. Towards this aim, we have developed an innovative magnetically-assisted electrospinning technique to selectively and precisely control gradients in fiber alignment.

Original languageEnglish (US)
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Number of pages1
ISBN (Electronic)9781510883901
StatePublished - Jan 1 2019
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: Apr 3 2019Apr 6 2019

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40
ISSN (Print)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
CountryUnited States
CitySeattle
Period4/3/194/6/19

Fingerprint

Electrospinning
Repair
Tissue
Fibers
Tendons
Bone
Bone and Bones
Tissue regeneration
Ligaments
Cartilage
Biocompatible Materials
Tissue Engineering
Tissue engineering
Biomaterials
Muscle
Regeneration
Fabrication
Muscles
Chemical analysis

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Biotechnology
  • Biomaterials
  • Materials Chemistry

Cite this

Kevin Tindell, R., & Holloway, J. (2019). Controlling fiber alignment using magnetically-assisted electrospinning for interfacial tissue repair. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40). Society for Biomaterials.

Controlling fiber alignment using magnetically-assisted electrospinning for interfacial tissue repair. / Kevin Tindell, R.; Holloway, Julianne.

Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 2019. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Kevin Tindell, R & Holloway, J 2019, Controlling fiber alignment using magnetically-assisted electrospinning for interfacial tissue repair. in Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium, vol. 40, Society for Biomaterials, 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence, Seattle, United States, 4/3/19.
Kevin Tindell R, Holloway J. Controlling fiber alignment using magnetically-assisted electrospinning for interfacial tissue repair. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials. 2019. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium).
Kevin Tindell, R. ; Holloway, Julianne. / Controlling fiber alignment using magnetically-assisted electrospinning for interfacial tissue repair. Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, 2019. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium).
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