Contrasting Patterns of Nuclear and mtDNA Diversity in Native American Populations

Ning Ning Yang, Stephane Mazières, Claudio Bravi, Nicolas Ray, Sijia Wang, Mari Wyn Burley, Gabriel Bedoya, Winston Rojas, Maria V. Parra, Julio A. Molina, Carla Gallo, Giovanni Poletti, Kim Hill, Ana Hurtado, Maria L. Petzl-Erler, Luiza T. Tsuneto, William Klitz, Ramiro Barrantes, Elena Llop, Francisco RothhammerDamian Labuda, Francisco M. Salzano, Maria Cátira Bortolini, Laurent Excoffier, Jean Michel Dugoujon, Andrés Ruiz-Linares

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

We report an integrated analysis of nuclear (autosomal, X- and Y-chromosome) short tandem repeat (STR) data and mtDNA D-loop sequences obtained in the same set of 22 Native populations from across the Americas. A north to south gradient of decreasing population diversity was observed, in agreement with a settlement of the Americas from the extreme northwest of the continent. This correlation is stronger with "least cost distances," which consider the coasts as facilitators of migration. Continent-wide estimates of population structure are highest for the Y-chromosome and lowest for the autosomes, consistent with the effective size of the different marker systems examined. Population differentiation is highest in East South America and lowest in Meso America and the Andean region. Regional analyses suggest a deviation from mutation-drift equilibrium consistent with population expansion in Meso America and the Andes and population contraction in Northwest and East South America. These data hint at an early divergence of Andean and non-Andean South Americans and at a contrasting demographic history for populations from these regions.

Original languageEnglish (US)
Pages (from-to)525-538
Number of pages14
JournalAnnals of Human Genetics
Volume74
Issue number6
DOIs
StatePublished - Nov 2010

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Keywords

  • Ameriindians
  • MtDNA
  • STRs
  • X-chromosome
  • Y-chromosome

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

Yang, N. N., Mazières, S., Bravi, C., Ray, N., Wang, S., Burley, M. W., Bedoya, G., Rojas, W., Parra, M. V., Molina, J. A., Gallo, C., Poletti, G., Hill, K., Hurtado, A., Petzl-Erler, M. L., Tsuneto, L. T., Klitz, W., Barrantes, R., Llop, E., ... Ruiz-Linares, A. (2010). Contrasting Patterns of Nuclear and mtDNA Diversity in Native American Populations. Annals of Human Genetics, 74(6), 525-538. https://doi.org/10.1111/j.1469-1809.2010.00608.x