Construction of optimal quality control for oligo arrays

Charles Colbourn, Alan C H Ling, Martin Tompa

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Motivation: Oligo arrays are important experimental tools for the high throughput measurement of gene expression levels. During production of oligo arrays, it is important to identify any faulty manufacturing step. Results: We describe a practical algorithm for the construction of optimal quality control designs that identify any faulty manufacturing step. The algorithm uses hillclimbing, a search technique from combinatorial optimization. We also present the results of using this algorithm on all practical quality control design sizes.

Original languageEnglish (US)
Pages (from-to)529-535
Number of pages7
JournalBioinformatics
Volume18
Issue number4
StatePublished - 2002

Fingerprint

Quality Control
Quality control
Optimal Control
Control Design
Manufacturing
Hill Climbing
Combinatorial optimization
Combinatorial Optimization
Gene expression
High Throughput
Gene Expression
Throughput

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Computer Science Applications
  • Computational Theory and Mathematics

Cite this

Colbourn, C., Ling, A. C. H., & Tompa, M. (2002). Construction of optimal quality control for oligo arrays. Bioinformatics, 18(4), 529-535.

Construction of optimal quality control for oligo arrays. / Colbourn, Charles; Ling, Alan C H; Tompa, Martin.

In: Bioinformatics, Vol. 18, No. 4, 2002, p. 529-535.

Research output: Contribution to journalArticle

Colbourn, C, Ling, ACH & Tompa, M 2002, 'Construction of optimal quality control for oligo arrays', Bioinformatics, vol. 18, no. 4, pp. 529-535.
Colbourn, Charles ; Ling, Alan C H ; Tompa, Martin. / Construction of optimal quality control for oligo arrays. In: Bioinformatics. 2002 ; Vol. 18, No. 4. pp. 529-535.
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