Construction of a single-chain interleukin-12-expressing retroviral vector and its application in cytokine gene therapy against experimental coccidioidomycosis

Agriculture & Biology

• coccidioidomycosis 100%
• retroviral vectors 92%
• gene therapy 85%
• interleukin-12 82%
• cytokines 57%
• Coccidioides immitis 35%
• mice 21%
• lungs 18%
• interferons 17%
• splenocytes 16%
• cells 12%
• interferon-gamma 8%
• cell-mediated immunity 8%
• protective effect 7%
• T-lymphocytes 6%
• macrophages 6%
• spleen 6%
• enzyme-linked immunosorbent assay 6%
• therapeutics 5%
• pathogens 4%
• liver 4%
• infection 3%
• tissues 3%

Medicine & Life Sciences

• Coccidioidomycosis 88%
• Interleukin-12 62%
• Genetic Therapy 56%
• Cytokines 37%
• Coccidioides 22%
• Spleen 17%
• Interferons 13%
• Lung 12%
• Cellular Immunity 7%
• Interferon-gamma 6%
• In Vitro Techniques 6%
• Cultured Cells 6%
• Complementary DNA 6%
• Enzyme-Linked Immunosorbent Assay 5%
• Macrophages 5%
• T-Lymphocytes 4%
• Liver 3%
• Growth 3%
• Serum 3%
• Therapeutics 2%