Considerations of Environmentally Relevant Test Conditions for Improved Evaluation of Ecological Hazards of Engineered Nanomaterials

Patricia A. Holden, Jorge L. Gardea-Torresdey, Fred Klaessig, Ronald F. Turco, Monika Mortimer, Kerstin Hund-Rinke, Elaine A. Cohen Hubal, David Avery, Damià Barceló, Renata Behra, Yoram Cohen, Laurence Deydier-Stephan, P. Lee Ferguson, Teresa F. Fernandes, Barbara Herr Harthorn, W. Matthew Henderson, Robert A. Hoke, Danail Hristozov, John M. Johnston, Agnes B. Kane & 20 others Larry Kapustka, Arturo A. Keller, Hunter S. Lenihan, Wess Lovell, Catherine J. Murphy, Roger M. Nisbet, Elijah J. Petersen, Edward R. Salinas, Martin Scheringer, Monita Sharma, David E. Speed, Yasir Sultan, Paul Westerhoff, Jason C. White, Mark R. Wiesner, Eva M. Wong, Baoshan Xing, Meghan Steele Horan, Hilary A. Godwin, André E. Nel

Research output: Contribution to journalReview article

90 Citations (Scopus)

Abstract

Engineered nanomaterials (ENMs) are increasingly entering the environment with uncertain consequences including potential ecological effects. Various research communities view differently whether ecotoxicological testing of ENMs should be conducted using environmentally relevant concentrations - where observing outcomes is difficult - versus higher ENM doses, where responses are observable. What exposure conditions are typically used in assessing ENM hazards to populations? What conditions are used to test ecosystem-scale hazards? What is known regarding actual ENMs in the environment, via measurements or modeling simulations? How should exposure conditions, ENM transformation, dose, and body burden be used in interpreting biological and computational findings for assessing risks? These questions were addressed in the context of this critical review. As a result, three main recommendations emerged. First, researchers should improve ecotoxicology of ENMs by choosing test end points, duration, and study conditions - including ENM test concentrations - that align with realistic exposure scenarios. Second, testing should proceed via tiers with iterative feedback that informs experiments at other levels of biological organization. Finally, environmental realism in ENM hazard assessments should involve greater coordination among ENM quantitative analysts, exposure modelers, and ecotoxicologists, across government, industry, and academia.

Original languageEnglish (US)
Pages (from-to)6124-6145
Number of pages22
JournalEnvironmental Science and Technology
Volume50
Issue number12
DOIs
StatePublished - Jun 21 2016

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Nanostructured materials
Hazards
hazard
ecotoxicology
hazard assessment
evaluation
exposure
test
ecosystem
industry
modeling
simulation
Testing
experiment
Ecosystems
dose
Feedback
Computer simulation

ASJC Scopus subject areas

  • Chemistry(all)
  • Environmental Chemistry

Cite this

Holden, P. A., Gardea-Torresdey, J. L., Klaessig, F., Turco, R. F., Mortimer, M., Hund-Rinke, K., ... Nel, A. E. (2016). Considerations of Environmentally Relevant Test Conditions for Improved Evaluation of Ecological Hazards of Engineered Nanomaterials. Environmental Science and Technology, 50(12), 6124-6145. https://doi.org/10.1021/acs.est.6b00608

Considerations of Environmentally Relevant Test Conditions for Improved Evaluation of Ecological Hazards of Engineered Nanomaterials. / Holden, Patricia A.; Gardea-Torresdey, Jorge L.; Klaessig, Fred; Turco, Ronald F.; Mortimer, Monika; Hund-Rinke, Kerstin; Cohen Hubal, Elaine A.; Avery, David; Barceló, Damià; Behra, Renata; Cohen, Yoram; Deydier-Stephan, Laurence; Ferguson, P. Lee; Fernandes, Teresa F.; Herr Harthorn, Barbara; Henderson, W. Matthew; Hoke, Robert A.; Hristozov, Danail; Johnston, John M.; Kane, Agnes B.; Kapustka, Larry; Keller, Arturo A.; Lenihan, Hunter S.; Lovell, Wess; Murphy, Catherine J.; Nisbet, Roger M.; Petersen, Elijah J.; Salinas, Edward R.; Scheringer, Martin; Sharma, Monita; Speed, David E.; Sultan, Yasir; Westerhoff, Paul; White, Jason C.; Wiesner, Mark R.; Wong, Eva M.; Xing, Baoshan; Steele Horan, Meghan; Godwin, Hilary A.; Nel, André E.

In: Environmental Science and Technology, Vol. 50, No. 12, 21.06.2016, p. 6124-6145.

Research output: Contribution to journalReview article

Holden, PA, Gardea-Torresdey, JL, Klaessig, F, Turco, RF, Mortimer, M, Hund-Rinke, K, Cohen Hubal, EA, Avery, D, Barceló, D, Behra, R, Cohen, Y, Deydier-Stephan, L, Ferguson, PL, Fernandes, TF, Herr Harthorn, B, Henderson, WM, Hoke, RA, Hristozov, D, Johnston, JM, Kane, AB, Kapustka, L, Keller, AA, Lenihan, HS, Lovell, W, Murphy, CJ, Nisbet, RM, Petersen, EJ, Salinas, ER, Scheringer, M, Sharma, M, Speed, DE, Sultan, Y, Westerhoff, P, White, JC, Wiesner, MR, Wong, EM, Xing, B, Steele Horan, M, Godwin, HA & Nel, AE 2016, 'Considerations of Environmentally Relevant Test Conditions for Improved Evaluation of Ecological Hazards of Engineered Nanomaterials', Environmental Science and Technology, vol. 50, no. 12, pp. 6124-6145. https://doi.org/10.1021/acs.est.6b00608
Holden, Patricia A. ; Gardea-Torresdey, Jorge L. ; Klaessig, Fred ; Turco, Ronald F. ; Mortimer, Monika ; Hund-Rinke, Kerstin ; Cohen Hubal, Elaine A. ; Avery, David ; Barceló, Damià ; Behra, Renata ; Cohen, Yoram ; Deydier-Stephan, Laurence ; Ferguson, P. Lee ; Fernandes, Teresa F. ; Herr Harthorn, Barbara ; Henderson, W. Matthew ; Hoke, Robert A. ; Hristozov, Danail ; Johnston, John M. ; Kane, Agnes B. ; Kapustka, Larry ; Keller, Arturo A. ; Lenihan, Hunter S. ; Lovell, Wess ; Murphy, Catherine J. ; Nisbet, Roger M. ; Petersen, Elijah J. ; Salinas, Edward R. ; Scheringer, Martin ; Sharma, Monita ; Speed, David E. ; Sultan, Yasir ; Westerhoff, Paul ; White, Jason C. ; Wiesner, Mark R. ; Wong, Eva M. ; Xing, Baoshan ; Steele Horan, Meghan ; Godwin, Hilary A. ; Nel, André E. / Considerations of Environmentally Relevant Test Conditions for Improved Evaluation of Ecological Hazards of Engineered Nanomaterials. In: Environmental Science and Technology. 2016 ; Vol. 50, No. 12. pp. 6124-6145.
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abstract = "Engineered nanomaterials (ENMs) are increasingly entering the environment with uncertain consequences including potential ecological effects. Various research communities view differently whether ecotoxicological testing of ENMs should be conducted using environmentally relevant concentrations - where observing outcomes is difficult - versus higher ENM doses, where responses are observable. What exposure conditions are typically used in assessing ENM hazards to populations? What conditions are used to test ecosystem-scale hazards? What is known regarding actual ENMs in the environment, via measurements or modeling simulations? How should exposure conditions, ENM transformation, dose, and body burden be used in interpreting biological and computational findings for assessing risks? These questions were addressed in the context of this critical review. As a result, three main recommendations emerged. First, researchers should improve ecotoxicology of ENMs by choosing test end points, duration, and study conditions - including ENM test concentrations - that align with realistic exposure scenarios. Second, testing should proceed via tiers with iterative feedback that informs experiments at other levels of biological organization. Finally, environmental realism in ENM hazard assessments should involve greater coordination among ENM quantitative analysts, exposure modelers, and ecotoxicologists, across government, industry, and academia.",
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AU - Holden, Patricia A.

AU - Gardea-Torresdey, Jorge L.

AU - Klaessig, Fred

AU - Turco, Ronald F.

AU - Mortimer, Monika

AU - Hund-Rinke, Kerstin

AU - Cohen Hubal, Elaine A.

AU - Avery, David

AU - Barceló, Damià

AU - Behra, Renata

AU - Cohen, Yoram

AU - Deydier-Stephan, Laurence

AU - Ferguson, P. Lee

AU - Fernandes, Teresa F.

AU - Herr Harthorn, Barbara

AU - Henderson, W. Matthew

AU - Hoke, Robert A.

AU - Hristozov, Danail

AU - Johnston, John M.

AU - Kane, Agnes B.

AU - Kapustka, Larry

AU - Keller, Arturo A.

AU - Lenihan, Hunter S.

AU - Lovell, Wess

AU - Murphy, Catherine J.

AU - Nisbet, Roger M.

AU - Petersen, Elijah J.

AU - Salinas, Edward R.

AU - Scheringer, Martin

AU - Sharma, Monita

AU - Speed, David E.

AU - Sultan, Yasir

AU - Westerhoff, Paul

AU - White, Jason C.

AU - Wiesner, Mark R.

AU - Wong, Eva M.

AU - Xing, Baoshan

AU - Steele Horan, Meghan

AU - Godwin, Hilary A.

AU - Nel, André E.

PY - 2016/6/21

Y1 - 2016/6/21

N2 - Engineered nanomaterials (ENMs) are increasingly entering the environment with uncertain consequences including potential ecological effects. Various research communities view differently whether ecotoxicological testing of ENMs should be conducted using environmentally relevant concentrations - where observing outcomes is difficult - versus higher ENM doses, where responses are observable. What exposure conditions are typically used in assessing ENM hazards to populations? What conditions are used to test ecosystem-scale hazards? What is known regarding actual ENMs in the environment, via measurements or modeling simulations? How should exposure conditions, ENM transformation, dose, and body burden be used in interpreting biological and computational findings for assessing risks? These questions were addressed in the context of this critical review. As a result, three main recommendations emerged. First, researchers should improve ecotoxicology of ENMs by choosing test end points, duration, and study conditions - including ENM test concentrations - that align with realistic exposure scenarios. Second, testing should proceed via tiers with iterative feedback that informs experiments at other levels of biological organization. Finally, environmental realism in ENM hazard assessments should involve greater coordination among ENM quantitative analysts, exposure modelers, and ecotoxicologists, across government, industry, and academia.

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