TY - JOUR
T1 - Consensus statement
T2 - Virus taxonomy in the age of metagenomics
AU - Simmonds, Peter
AU - Adams, Mike J.
AU - Benk, Mária
AU - Breitbart, Mya
AU - Brister, J. Rodney
AU - Carstens, Eric B.
AU - Davison, Andrew J.
AU - Delwart, Eric
AU - Gorbalenya, Alexander E.
AU - Harrach, Balázs
AU - Hull, Roger
AU - King, Andrew M.Q.
AU - Koonin, Eugene V.
AU - Krupovic, Mart
AU - Kuhn, Jens H.
AU - Lefkowitz, Elliot J.
AU - Nibert, Max L.
AU - Orton, Richard
AU - Roossinck, Marilyn J.
AU - Sabanadzovic, Sead
AU - Sullivan, Matthew B.
AU - Suttle, Curtis A.
AU - Tesh, Robert B.
AU - Van Der Vlugt, René A.
AU - Varsani, Arvind
AU - Zerbini, F. Murilo
N1 - Funding Information:
The workshop and discussions were funded by the Wellcome Trust (grant WT108418AIA). The authors thank the members of the International Committee on Taxonomy of Viruses (ICTV) Executive Committee who did not attend (A. Kropinski, R. Harrison, H. Sanfaçon, A. Mushegian, N. Knowles and S. Siddell) for thoughtful comments and discussion, and S. Roux from the Department of Microbiology at Ohio State University, USA, for the preparation of figure 1. B.H. and M. Benko were supported by the Hungarian Scientific Research Fund (OTKA; grants NN107632 and K100163, respectively). The work of A.E.G. was partially supported by the European Union's Horizon 2020 research and innovation programme (under grant agreement number 653316; the European Virus Archive goes Global, EVAg). R.A.v.d.V. was partly supported by the EU Cooperation in Science and Technology (COST) programme (action FA1407). S.S. acknowledges partial financial support from Mississippi State University (MSU)-Mississippi Agricultural and Forestry Experiment Station (MAFES) Strategic Research Initiative grants. The work of E.D. was supported by the US National Heart, Lung, and Blood Institute (NHLBI; grant R01 HL105770). Research by J.R.B. and E.V.K. was supported, in part, by the Intramural Research Program of the US National Institutes of Health (NIH), US National Library of Medicine. M.Breitbart was supported through the Assembling the Tree of Life Programme of the US National Science Foundation (grant DEB-1239976). M.B.S. was supported by an award from the Gordon and Betty Moore Foundation (number 3790). The involvement of J.H.K. was supported, in part, through the prime contract of the Battelle Memorial Institute with the US National Institute of Allergy and Infectious Diseases (NIAID) under contract number HHSN272200700016I. A subcontractor to the Battelle Memorial Institute who carried out this work is J.H.K., who is an employee of Tunnell Government Services, Inc. The views and conclusions that are contained in this document are those of the authors and should not be interpreted as necessarily representing the official policies, either expressed or implied, of the US Department of Health and Human Services or of the institutions and companies that are affiliated with the authors.
PY - 2017/2/13
Y1 - 2017/2/13
N2 - The number and diversity of viral sequences that are identified in metagenomic data far exceeds that of experimentally characterized virus isolates. In a recent workshop, a panel of experts discussed the proposal that, with appropriate quality control, viruses that are known only from metagenomic data can, and should be, incorporated into the official classification scheme of the International Committee on Taxonomy of Viruses (ICTV). Although a taxonomy that is based on metagenomic sequence data alone represents a substantial departure from the traditional reliance on phenotypic properties, the development of a robust framework for sequence-based virus taxonomy is indispensable for the comprehensive characterization of the global virome. In this Consensus Statement article, we consider the rationale for why metagenomic sequence data should, and how it can, be incorporated into the ICTV taxonomy, and present proposals that have been endorsed by the Executive Committee of the ICTV.
AB - The number and diversity of viral sequences that are identified in metagenomic data far exceeds that of experimentally characterized virus isolates. In a recent workshop, a panel of experts discussed the proposal that, with appropriate quality control, viruses that are known only from metagenomic data can, and should be, incorporated into the official classification scheme of the International Committee on Taxonomy of Viruses (ICTV). Although a taxonomy that is based on metagenomic sequence data alone represents a substantial departure from the traditional reliance on phenotypic properties, the development of a robust framework for sequence-based virus taxonomy is indispensable for the comprehensive characterization of the global virome. In this Consensus Statement article, we consider the rationale for why metagenomic sequence data should, and how it can, be incorporated into the ICTV taxonomy, and present proposals that have been endorsed by the Executive Committee of the ICTV.
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UR - http://www.scopus.com/inward/citedby.url?scp=85008394347&partnerID=8YFLogxK
U2 - 10.1038/nrmicro.2016.177
DO - 10.1038/nrmicro.2016.177
M3 - Article
C2 - 28134265
AN - SCOPUS:85008394347
SN - 1740-1526
VL - 15
SP - 161
EP - 168
JO - Nature Reviews Microbiology
JF - Nature Reviews Microbiology
IS - 3
ER -