TY - JOUR
T1 - Connectivity strength of dissociable striatal tracts predict individual differences in temporal discounting
AU - van den Bos, Wouter
AU - Rodriguez, Christian A.
AU - Schweitzer, Julie B.
AU - McClure, Samuel M.
PY - 2014
Y1 - 2014
N2 - Large individual differences existin the ability to delay gratification for the sake of satisfying longer-term goals. These individual differences are commonly assayed by studying intertemporal preferences, as revealed by choices between immediate and delayed rewards. In the brain, reward-based and goal-oriented decisions are believed to rely on the striatum and its interactions with other cortical and subcortical networks. However, itremains unknown whichspecific cortical-striatal tracts are involvedin intertemporal decision making. We use connectivity analyses in both structural and functional MRI to further our understanding of the relationship between distinct corticostriatal networks and intertemporal preferences in humans. Our results revealed distinct striatal pathways that are differentially related to delay discounting. Structural and functional connectivity between striatum and lateral prefrontal cortex was associated with increased patience, whereas connectivity between subcortical areas and striatum was associated with increased impulsivity. These findings provide novel insights into how the anatomy and functioning of striatal circuits mediate individual differences in intertemporal choice.
AB - Large individual differences existin the ability to delay gratification for the sake of satisfying longer-term goals. These individual differences are commonly assayed by studying intertemporal preferences, as revealed by choices between immediate and delayed rewards. In the brain, reward-based and goal-oriented decisions are believed to rely on the striatum and its interactions with other cortical and subcortical networks. However, itremains unknown whichspecific cortical-striatal tracts are involvedin intertemporal decision making. We use connectivity analyses in both structural and functional MRI to further our understanding of the relationship between distinct corticostriatal networks and intertemporal preferences in humans. Our results revealed distinct striatal pathways that are differentially related to delay discounting. Structural and functional connectivity between striatum and lateral prefrontal cortex was associated with increased patience, whereas connectivity between subcortical areas and striatum was associated with increased impulsivity. These findings provide novel insights into how the anatomy and functioning of striatal circuits mediate individual differences in intertemporal choice.
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U2 - 10.1523/JNEUROSCI.4105-13.2014
DO - 10.1523/JNEUROSCI.4105-13.2014
M3 - Article
C2 - 25080591
AN - SCOPUS:84904994775
SN - 0270-6474
VL - 34
SP - 10298
EP - 10310
JO - Journal of Neuroscience
JF - Journal of Neuroscience
IS - 31
ER -