Connecting COX-2 and Wnt in cancer

F. Gregory Buchanan, Raymond N. DuBois

Research output: Contribution to journalShort surveypeer-review

88 Scopus citations

Abstract

Both the cyclooxygenase-2 (COX-2) and Wnt signaling cascades are active in the majority of colorectal cancers. Nevertheless, a direct link between these two key pathways has remained elusive. Recent reports show that one of the bioactive products of COX-2, prostaglandin E2, activates components of the canonical Wnt signaling system. The findings reviewed below reveal important crosstalk between these pathways, which may provide opportunities for the development of new drugs for treatment and/or prevention of colorectal cancer.

Original languageEnglish (US)
Pages (from-to)6-8
Number of pages3
JournalCancer cell
Volume9
Issue number1
DOIs
StatePublished - Jan 2006
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research

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