TY - JOUR
T1 - Conformational flexibility in DNA
T2 - Ion mediated interactions and the shape of genes
AU - Lindsay, Stuart
N1 - Funding Information:
ACKNOWLEDGEMENTS Tom Weidlich carried out the Raman studies of interhelical interactions described here_ Nongjain Tao was responsible for the studies of DNA hydration. STM studies were con- ducted with Larry Nagahara and Tom Thundat_ Samples have been supplie3 by Allan Rupprecht and Randy Rill-This work was supported by the Officeof Naval Research, the National Science Foundation and the office of the Vice President for Research, ASU.
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1989/10
Y1 - 1989/10
N2 - Forces external to the double helix are at least as important as its internal structure in determining its geometry. Local interactions among the bases, hydrogen bonding in the primary shell, and collective ('hydrophobic' and 'hydration force') interactions probably dominate local structure, while many-body interactions in the diffuse ion cloud determine the overall conformation. In the condensed state, ion-mediated interactions between neighboring molecules dominate the conformational stability. The wide range of structural variation, and its control by external interactions, can be visualized with a tunneling microscope operated in water.
AB - Forces external to the double helix are at least as important as its internal structure in determining its geometry. Local interactions among the bases, hydrogen bonding in the primary shell, and collective ('hydrophobic' and 'hydration force') interactions probably dominate local structure, while many-body interactions in the diffuse ion cloud determine the overall conformation. In the condensed state, ion-mediated interactions between neighboring molecules dominate the conformational stability. The wide range of structural variation, and its control by external interactions, can be visualized with a tunneling microscope operated in water.
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U2 - 10.1016/0167-7322(89)80087-X
DO - 10.1016/0167-7322(89)80087-X
M3 - Article
AN - SCOPUS:0010818499
SN - 0167-7322
VL - 41
SP - 315
EP - 325
JO - Journal of Molecular Liquids
JF - Journal of Molecular Liquids
IS - C
ER -