Conformational flexibility in DNA: Ion mediated interactions and the shape of genes

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Forces external to the double helix are at least as important as its internal structure in determining its geometry. Local interactions among the bases, hydrogen bonding in the primary shell, and collective ('hydrophobic' and 'hydration force') interactions probably dominate local structure, while many-body interactions in the diffuse ion cloud determine the overall conformation. In the condensed state, ion-mediated interactions between neighboring molecules dominate the conformational stability. The wide range of structural variation, and its control by external interactions, can be visualized with a tunneling microscope operated in water.

Original languageEnglish (US)
Pages (from-to)315-325
Number of pages11
JournalJournal of Molecular Liquids
Volume41
Issue numberC
DOIs
StatePublished - Oct 1989

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Condensed Matter Physics
  • Spectroscopy
  • Physical and Theoretical Chemistry
  • Materials Chemistry

Fingerprint Dive into the research topics of 'Conformational flexibility in DNA: Ion mediated interactions and the shape of genes'. Together they form a unique fingerprint.

Cite this