Conformational changes in adhesive proteins modulate their adhesive function

T. Ugarova, F. R. Agbanyo, E. F. Plow

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

A large family of glycoproteins mediates cell adhesion by binding to cellular receptors. As a group, these adhesive proteins are large in size, multi-domainal in composition, and are capable of self-association. A general property of the adhesive proteins is their susceptibility to structural modulation, and conformational change provides a mechanism for regulation of their adhesive functions. To illustrate this concept, conformational alterations of thrombospondin, fibrinogen and fibronectin are shown to modulate their adhesive potential. Thus, conformational status of the adhesive proteins contributes to the regulation of cell adhesion.

Original languageEnglish (US)
Pages (from-to)253-257
Number of pages5
JournalThrombosis and Haemostasis
Volume74
Issue number1
StatePublished - Jan 1 1995
Externally publishedYes

ASJC Scopus subject areas

  • Hematology

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