Computed Tomography-Based Texture Analysis to Determine Human Papillomavirus Status of Oropharyngeal Squamous Cell Carcinoma

Sara Ranjbar, Shuluo Ning, Christine M. Zwart, Christopher P. Wood, Steven M. Weindling, Teresa Wu, J. Ross Mitchell, Jing Li, Joseph M. Hoxworth

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective To determine whether machine learning can accurately classify human papillomavirus (HPV) status of oropharyngeal squamous cell carcinoma (OPSCC) using computed tomography (CT)-based texture analysis. Methods Texture analyses were retrospectively applied to regions of interest from OPSCC primary tumors on contrast-enhanced neck CT, and machine learning was used to create a model that classified HPV status with the highest accuracy. Results were compared against the blinded review of 2 neuroradiologists. Results The HPV-positive (n = 92) and-negative (n = 15) cohorts were well matched clinically. Neuroradiologist classification accuracies for HPV status (44.9%, 55.1%) were not significantly different (P = 0.13), and there was a lack of agreement between the 2 neuroradiologists (κ =-0.145). The best machine learning model had an accuracy of 75.7%, which was greater than either neuroradiologist (P < 0.001, P = 0.002). Conclusions Useful diagnostic information regarding HPV infection can be extracted from the CT appearance of OPSCC beyond what is apparent to the trained human eye.

Original languageEnglish (US)
Pages (from-to)299-305
Number of pages7
JournalJournal of Computer Assisted Tomography
Volume42
Issue number2
DOIs
StatePublished - Mar 1 2018

Fingerprint

Squamous Cell Carcinoma
Tomography
Papillomavirus Infections
Neck
Machine Learning
Neoplasms

Keywords

  • human papillomavirus
  • machine learning
  • oropharyngeal cancer
  • oropharynx
  • radiomics
  • squamous cell carcinoma
  • texture analysis

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Computed Tomography-Based Texture Analysis to Determine Human Papillomavirus Status of Oropharyngeal Squamous Cell Carcinoma. / Ranjbar, Sara; Ning, Shuluo; Zwart, Christine M.; Wood, Christopher P.; Weindling, Steven M.; Wu, Teresa; Ross Mitchell, J.; Li, Jing; Hoxworth, Joseph M.

In: Journal of Computer Assisted Tomography, Vol. 42, No. 2, 01.03.2018, p. 299-305.

Research output: Contribution to journalArticle

Ranjbar, Sara ; Ning, Shuluo ; Zwart, Christine M. ; Wood, Christopher P. ; Weindling, Steven M. ; Wu, Teresa ; Ross Mitchell, J. ; Li, Jing ; Hoxworth, Joseph M. / Computed Tomography-Based Texture Analysis to Determine Human Papillomavirus Status of Oropharyngeal Squamous Cell Carcinoma. In: Journal of Computer Assisted Tomography. 2018 ; Vol. 42, No. 2. pp. 299-305.
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