Computational Prediction of Bacteriophage Host Ranges

Cyril J. Versoza, Susanne P. Pfeifer

Research output: Contribution to journalReview articlepeer-review

Abstract

Increased antibiotic resistance has prompted the development of bacteriophage agents for a multitude of applications in agriculture, biotechnology, and medicine. A key factor in the choice of agents for these applications is the host range of a bacteriophage, i.e., the bacterial genera, species, and strains a bacteriophage is able to infect. Although experimental explorations of host ranges remain the gold standard, such investigations are inherently limited to a small number of viruses and bacteria amendable to cultivation. Here, we review recently developed bioinformatic tools that offer a promising and high-throughput alternative by computationally predicting the putative host ranges of bacteriophages, including those challenging to grow in laboratory environments.

Original languageEnglish (US)
Article number149
JournalMicroorganisms
Volume10
Issue number1
DOIs
StatePublished - Jan 2022

Keywords

  • Bacterial hosts
  • Bacteriophages
  • Bioinformatic tools
  • Host ranges

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Virology

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