Computational modeling of oscillating fins that "catch and release" targeted nanoparticles in bilayer flows

Ya Liu, Amitabh Bhattacharya, Olga Kuksenok, Ximin He, Michael Aizenberg, Joanna Aizenberg, Anna C. Balazs

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

A number of physiological processes in living organisms involve the selective "catch and release" of biomolecules. Inspired by these biological processes, we use computational modeling to design synthetic systems that can controllably catch, transport, and release specific molecules within the surrounding solution, and, thus, could be harnessed for effective separation processes within microfluidic devices. Our system consists of an array of oscillating, microscopic fins that are anchored onto the floor of a microchannel and immersed in a flowing bilayer fluid. The oscillations drive the fins to repeatedly extend into the upper fluid and then tilt into the lower stream. The fins exhibit a specified wetting interaction with the fluids and specific adhesive interactions with nanoparticles in the solution. With this setup, we determine conditions where the oscillating fins can selectively bind, and thus, "catch" target nanoparticles within the upper fluid stream and then release these particles into the lower stream. We isolate the effects of varying the wetting interaction and the fins' oscillation modes on the effective extraction of target species from the upper stream. Our findings provide fundamental insights into the system's complex dynamics and yield guidelines for fabricating devices for the detection and separation of target molecules from complex fluids.

Original languageEnglish (US)
Pages (from-to)1374-1384
Number of pages11
JournalSoft Matter
Volume12
Issue number5
DOIs
StatePublished - 2016

Fingerprint

fins
Nanoparticles
nanoparticles
Fluids
fluids
wetting
Wetting
oscillations
Molecules
microfluidic devices
interactions
Biomolecules
microchannels
Microchannels
complex systems
organisms
Microfluidics
adhesives
molecules
Adhesives

ASJC Scopus subject areas

  • Chemistry(all)
  • Condensed Matter Physics

Cite this

Liu, Y., Bhattacharya, A., Kuksenok, O., He, X., Aizenberg, M., Aizenberg, J., & Balazs, A. C. (2016). Computational modeling of oscillating fins that "catch and release" targeted nanoparticles in bilayer flows. Soft Matter, 12(5), 1374-1384. https://doi.org/10.1039/c5sm02752g

Computational modeling of oscillating fins that "catch and release" targeted nanoparticles in bilayer flows. / Liu, Ya; Bhattacharya, Amitabh; Kuksenok, Olga; He, Ximin; Aizenberg, Michael; Aizenberg, Joanna; Balazs, Anna C.

In: Soft Matter, Vol. 12, No. 5, 2016, p. 1374-1384.

Research output: Contribution to journalArticle

Liu, Y, Bhattacharya, A, Kuksenok, O, He, X, Aizenberg, M, Aizenberg, J & Balazs, AC 2016, 'Computational modeling of oscillating fins that "catch and release" targeted nanoparticles in bilayer flows', Soft Matter, vol. 12, no. 5, pp. 1374-1384. https://doi.org/10.1039/c5sm02752g
Liu, Ya ; Bhattacharya, Amitabh ; Kuksenok, Olga ; He, Ximin ; Aizenberg, Michael ; Aizenberg, Joanna ; Balazs, Anna C. / Computational modeling of oscillating fins that "catch and release" targeted nanoparticles in bilayer flows. In: Soft Matter. 2016 ; Vol. 12, No. 5. pp. 1374-1384.
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