Compressed sensing to accelerate magnetic resonance spectroscopic imaging: Evaluation and application to <sup>23</sup>Na-imaging of mouse hearts

Mahon L. Maguire, Sairam Geethanath, Craig A. Lygate, Vikram Kodibagkar, Jürgen E. Schneider

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Abstract

Background: Magnetic Resonance Spectroscopic Imaging (MRSI) has wide applicability for non-invasive biochemical assessment in clinical and pre-clinical applications but suffers from long scan times. Compressed sensing (CS) has been successfully applied to clinical <sup>1</sup>H MRSI, however a detailed evaluation of CS for conventional chemical shift imaging is lacking. Here we evaluate the performance of CS accelerated MRSI, and specifically apply it to accelerate <sup>23</sup>Na-MRSI on mouse hearts in vivo at 9.4 T. Methods: Synthetic phantom data representing a simplified section across a mouse thorax were used to evaluate the fidelity of the CS reconstruction for varying levels of under-sampling, resolution and signal-to-noise ratios (SNR). The amplitude of signals arising from within a compartment, and signal contamination arising from outside the compartment relative to noise-free Fourier-transformed (FT) data were determined. Simulation results were subsequently verified experimentally in phantoms and in three mouse hearts in vivo. Results: CS reconstructed MRSI data are scaled linearly relative to absolute signal intensities from the fully-sampled FT reconstructed case (R<sup>2</sup> > 0.8, p-value < 0.001). Higher acceleration factors resulted in a denoising of the reconstructed spectra, but also in an increased blurring of compartment boundaries, particularly at lower spatial resolutions. Increasing resolution and SNR decreased cross-compartment contamination and yielded signal amplitudes closer to the FT data. Proof-of-concept high-resolution, 3-fold accelerated <sup>23</sup>Na-amplitude maps of murine myocardium could be obtained within ∼23 mins. Conclusions: Relative signal amplitudes (i.e. metabolite ratios) and absolute quantification of metabolite concentrations can be accurately determined with up to 5-fold under-sampled, CS-reconstructed MRSI. Although this work focused on murine cardiac <sup>23</sup>Na-MRSI, the results are equally applicable to other nuclei and tissues (e.g. <sup>1</sup>H MRSI in brain). Significant reduction in MRSI scan time will reduce the burden on the subject, increase scanner throughput, and may open new avenues for (pre-) clinical metabolic studies.

Original languageEnglish (US)
Article number42
JournalJournal of Cardiovascular Magnetic Resonance
Volume17
Issue number1
DOIs
StatePublished - Jun 15 2015

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Keywords

  • Chemical shift imaging
  • Compressed sensing
  • Magnetic resonance spectroscopic imaging
  • Mouse
  • Sodium

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Family Practice

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