Complications among colorectal cancer survivors: SF-6D preference-weighted quality of life scores

Mark C. Hornbrook, Christopher S. Wendel, Stephen Joel Coons, Marcia Grant, Lisa J. Herrinton, M. Jane Mohler, Carol M. Baldwin, Carmit K. McMullen, Sylvan B. Green, Andrea Altschuler, Susan M. Rawl, Robert S. Krouse

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Background: Societal preference-weighted health-related quality of life (HRQOL) scores enable comparing multidimensional health states across diseases and treatments for research and policy. Objective: To assess the effects of living with a permanent intestinal stoma, compared with a major bowel resection, among colorectal cancer (CRC) survivors. Research Design: Cross-sectional multivariate linear regression analysis to explain preference-weighted HRQOL scores. Subjects: In all, 640 CRC survivors (5 years) from 3 group model health maintenance organizations; ostomates and nonostomates with colorectal resections for CRC were matched on gender, age (±5 years), time since diagnosis, and tumor site (rectum vs. colon). Measures: SF-6D scoring system was applied to Medical Outcomes Study Short Form-36 version 2 (SF-36v2); City of Hope Quality of Life-Ostomy; and Charlson-Deyo comorbidity index. Methods: Survey of CRC survivors linked to respondents' clinical data extracted from health maintenance organization files. Results: Response rate was 52%. Ostomates and nonostomates had similar sociodemographic characteristics. Mean SF-6D score was 0.69 for ostomates, compared with 0.73 for nonostomates (P < 0.001), but other factors explained this difference. Complications of initial cancer surgery, and previous year comorbidity burden, and hospital use were negatively associated with SF-6D scores, whereas household income was positively associated. Conclusions: CRC survivors' SF-6D scores were not associated with living with a permanent ostomy after other factors were taken into account. Surgical complications, comorbidities, and metastatic disease lowered the preference-weighted HRQOL of CRC survivors with and without ostomies. Further research to understand and reduce late complications from CRC surgeries as well as associated depression is warranted.

Original languageEnglish (US)
Pages (from-to)321-326
Number of pages6
JournalMedical Care
Volume49
Issue number3
DOIs
StatePublished - Mar 2011

Fingerprint

Survivors
Colorectal Neoplasms
Quality of Life
Ostomy
Comorbidity
Health Maintenance Organizations
Hope
Colorectal Surgery
Research
Rectum
Linear Models
Neoplasms
Colon
Research Design
Regression Analysis
Outcome Assessment (Health Care)
Depression
Health

Keywords

  • colorectal cancer
  • HRQOL
  • ostomies
  • stomas
  • survivorship
  • utilities

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Hornbrook, M. C., Wendel, C. S., Coons, S. J., Grant, M., Herrinton, L. J., Mohler, M. J., ... Krouse, R. S. (2011). Complications among colorectal cancer survivors: SF-6D preference-weighted quality of life scores. Medical Care, 49(3), 321-326. https://doi.org/10.1097/MLR.0b013e31820194c8

Complications among colorectal cancer survivors : SF-6D preference-weighted quality of life scores. / Hornbrook, Mark C.; Wendel, Christopher S.; Coons, Stephen Joel; Grant, Marcia; Herrinton, Lisa J.; Mohler, M. Jane; Baldwin, Carol M.; McMullen, Carmit K.; Green, Sylvan B.; Altschuler, Andrea; Rawl, Susan M.; Krouse, Robert S.

In: Medical Care, Vol. 49, No. 3, 03.2011, p. 321-326.

Research output: Contribution to journalArticle

Hornbrook, MC, Wendel, CS, Coons, SJ, Grant, M, Herrinton, LJ, Mohler, MJ, Baldwin, CM, McMullen, CK, Green, SB, Altschuler, A, Rawl, SM & Krouse, RS 2011, 'Complications among colorectal cancer survivors: SF-6D preference-weighted quality of life scores', Medical Care, vol. 49, no. 3, pp. 321-326. https://doi.org/10.1097/MLR.0b013e31820194c8
Hornbrook MC, Wendel CS, Coons SJ, Grant M, Herrinton LJ, Mohler MJ et al. Complications among colorectal cancer survivors: SF-6D preference-weighted quality of life scores. Medical Care. 2011 Mar;49(3):321-326. https://doi.org/10.1097/MLR.0b013e31820194c8
Hornbrook, Mark C. ; Wendel, Christopher S. ; Coons, Stephen Joel ; Grant, Marcia ; Herrinton, Lisa J. ; Mohler, M. Jane ; Baldwin, Carol M. ; McMullen, Carmit K. ; Green, Sylvan B. ; Altschuler, Andrea ; Rawl, Susan M. ; Krouse, Robert S. / Complications among colorectal cancer survivors : SF-6D preference-weighted quality of life scores. In: Medical Care. 2011 ; Vol. 49, No. 3. pp. 321-326.
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abstract = "Background: Societal preference-weighted health-related quality of life (HRQOL) scores enable comparing multidimensional health states across diseases and treatments for research and policy. Objective: To assess the effects of living with a permanent intestinal stoma, compared with a major bowel resection, among colorectal cancer (CRC) survivors. Research Design: Cross-sectional multivariate linear regression analysis to explain preference-weighted HRQOL scores. Subjects: In all, 640 CRC survivors (5 years) from 3 group model health maintenance organizations; ostomates and nonostomates with colorectal resections for CRC were matched on gender, age (±5 years), time since diagnosis, and tumor site (rectum vs. colon). Measures: SF-6D scoring system was applied to Medical Outcomes Study Short Form-36 version 2 (SF-36v2); City of Hope Quality of Life-Ostomy; and Charlson-Deyo comorbidity index. Methods: Survey of CRC survivors linked to respondents' clinical data extracted from health maintenance organization files. Results: Response rate was 52{\%}. Ostomates and nonostomates had similar sociodemographic characteristics. Mean SF-6D score was 0.69 for ostomates, compared with 0.73 for nonostomates (P < 0.001), but other factors explained this difference. Complications of initial cancer surgery, and previous year comorbidity burden, and hospital use were negatively associated with SF-6D scores, whereas household income was positively associated. Conclusions: CRC survivors' SF-6D scores were not associated with living with a permanent ostomy after other factors were taken into account. Surgical complications, comorbidities, and metastatic disease lowered the preference-weighted HRQOL of CRC survivors with and without ostomies. Further research to understand and reduce late complications from CRC surgeries as well as associated depression is warranted.",
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AU - Wendel, Christopher S.

AU - Coons, Stephen Joel

AU - Grant, Marcia

AU - Herrinton, Lisa J.

AU - Mohler, M. Jane

AU - Baldwin, Carol M.

AU - McMullen, Carmit K.

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N2 - Background: Societal preference-weighted health-related quality of life (HRQOL) scores enable comparing multidimensional health states across diseases and treatments for research and policy. Objective: To assess the effects of living with a permanent intestinal stoma, compared with a major bowel resection, among colorectal cancer (CRC) survivors. Research Design: Cross-sectional multivariate linear regression analysis to explain preference-weighted HRQOL scores. Subjects: In all, 640 CRC survivors (5 years) from 3 group model health maintenance organizations; ostomates and nonostomates with colorectal resections for CRC were matched on gender, age (±5 years), time since diagnosis, and tumor site (rectum vs. colon). Measures: SF-6D scoring system was applied to Medical Outcomes Study Short Form-36 version 2 (SF-36v2); City of Hope Quality of Life-Ostomy; and Charlson-Deyo comorbidity index. Methods: Survey of CRC survivors linked to respondents' clinical data extracted from health maintenance organization files. Results: Response rate was 52%. Ostomates and nonostomates had similar sociodemographic characteristics. Mean SF-6D score was 0.69 for ostomates, compared with 0.73 for nonostomates (P < 0.001), but other factors explained this difference. Complications of initial cancer surgery, and previous year comorbidity burden, and hospital use were negatively associated with SF-6D scores, whereas household income was positively associated. Conclusions: CRC survivors' SF-6D scores were not associated with living with a permanent ostomy after other factors were taken into account. Surgical complications, comorbidities, and metastatic disease lowered the preference-weighted HRQOL of CRC survivors with and without ostomies. Further research to understand and reduce late complications from CRC surgeries as well as associated depression is warranted.

AB - Background: Societal preference-weighted health-related quality of life (HRQOL) scores enable comparing multidimensional health states across diseases and treatments for research and policy. Objective: To assess the effects of living with a permanent intestinal stoma, compared with a major bowel resection, among colorectal cancer (CRC) survivors. Research Design: Cross-sectional multivariate linear regression analysis to explain preference-weighted HRQOL scores. Subjects: In all, 640 CRC survivors (5 years) from 3 group model health maintenance organizations; ostomates and nonostomates with colorectal resections for CRC were matched on gender, age (±5 years), time since diagnosis, and tumor site (rectum vs. colon). Measures: SF-6D scoring system was applied to Medical Outcomes Study Short Form-36 version 2 (SF-36v2); City of Hope Quality of Life-Ostomy; and Charlson-Deyo comorbidity index. Methods: Survey of CRC survivors linked to respondents' clinical data extracted from health maintenance organization files. Results: Response rate was 52%. Ostomates and nonostomates had similar sociodemographic characteristics. Mean SF-6D score was 0.69 for ostomates, compared with 0.73 for nonostomates (P < 0.001), but other factors explained this difference. Complications of initial cancer surgery, and previous year comorbidity burden, and hospital use were negatively associated with SF-6D scores, whereas household income was positively associated. Conclusions: CRC survivors' SF-6D scores were not associated with living with a permanent ostomy after other factors were taken into account. Surgical complications, comorbidities, and metastatic disease lowered the preference-weighted HRQOL of CRC survivors with and without ostomies. Further research to understand and reduce late complications from CRC surgeries as well as associated depression is warranted.

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