Abstract

Structural DNA nanotechnology and the DNA origami technique, in particular, have provided a range of spatially addressable two- and three-dimensional nanostructures. These structures are, however, typically formed of tightly packed parallel helices. The development of wireframe structures should allow the creation of novel designs with unique functionalities, but engineering complex wireframe architectures with arbitrarily designed connections between selected vertices in three-dimensional space remains a challenge. Here, we report a design strategy for fabricating finite-size wireframe DNA nanostructures with high complexity and programmability. In our approach, the vertices are represented by n×4 multi-arm junctions (n=2-10) with controlled angles, and the lines are represented by antiparallel DNA crossover tiles of variable lengths. Scaffold strands are used to integrate the vertices and lines into fully assembled structures displaying intricate architectures. To demonstrate the versatility of the technique, a series of two-dimensional designs including quasi-crystalline patterns and curvilinear arrays or variable curvatures, and three-dimensional designs including a complex snub cube and a reconfigurable Archimedean solid were constructed.

Original languageEnglish (US)
Pages (from-to)779-784
Number of pages6
JournalNature Nanotechnology
Volume10
Issue number9
DOIs
StatePublished - Sep 3 2015

Fingerprint

Nanostructures
apexes
DNA
deoxyribonucleic acid
tiles
versatility
Tile
nanotechnology
Nanotechnology
Scaffolds
strands
helices
crossovers
curvature
engineering
Crystalline materials

ASJC Scopus subject areas

  • Bioengineering
  • Biomedical Engineering
  • Materials Science(all)
  • Electrical and Electronic Engineering
  • Condensed Matter Physics
  • Atomic and Molecular Physics, and Optics

Cite this

Complex wireframe DNA origami nanostructures with multi-arm junction vertices. / Zhang, Fei; Jiang, Shuoxing; Wu, Siyu; Li, Yulin; Mao, Chengde; Liu, Yan; Yan, Hao.

In: Nature Nanotechnology, Vol. 10, No. 9, 03.09.2015, p. 779-784.

Research output: Contribution to journalArticle

Zhang, Fei ; Jiang, Shuoxing ; Wu, Siyu ; Li, Yulin ; Mao, Chengde ; Liu, Yan ; Yan, Hao. / Complex wireframe DNA origami nanostructures with multi-arm junction vertices. In: Nature Nanotechnology. 2015 ; Vol. 10, No. 9. pp. 779-784.
@article{1bd5b06e64bf4f5e88632d2f53f77494,
title = "Complex wireframe DNA origami nanostructures with multi-arm junction vertices",
abstract = "Structural DNA nanotechnology and the DNA origami technique, in particular, have provided a range of spatially addressable two- and three-dimensional nanostructures. These structures are, however, typically formed of tightly packed parallel helices. The development of wireframe structures should allow the creation of novel designs with unique functionalities, but engineering complex wireframe architectures with arbitrarily designed connections between selected vertices in three-dimensional space remains a challenge. Here, we report a design strategy for fabricating finite-size wireframe DNA nanostructures with high complexity and programmability. In our approach, the vertices are represented by n×4 multi-arm junctions (n=2-10) with controlled angles, and the lines are represented by antiparallel DNA crossover tiles of variable lengths. Scaffold strands are used to integrate the vertices and lines into fully assembled structures displaying intricate architectures. To demonstrate the versatility of the technique, a series of two-dimensional designs including quasi-crystalline patterns and curvilinear arrays or variable curvatures, and three-dimensional designs including a complex snub cube and a reconfigurable Archimedean solid were constructed.",
author = "Fei Zhang and Shuoxing Jiang and Siyu Wu and Yulin Li and Chengde Mao and Yan Liu and Hao Yan",
year = "2015",
month = "9",
day = "3",
doi = "10.1038/nnano.2015.162",
language = "English (US)",
volume = "10",
pages = "779--784",
journal = "Nature Nanotechnology",
issn = "1748-3387",
publisher = "Nature Publishing Group",
number = "9",

}

TY - JOUR

T1 - Complex wireframe DNA origami nanostructures with multi-arm junction vertices

AU - Zhang, Fei

AU - Jiang, Shuoxing

AU - Wu, Siyu

AU - Li, Yulin

AU - Mao, Chengde

AU - Liu, Yan

AU - Yan, Hao

PY - 2015/9/3

Y1 - 2015/9/3

N2 - Structural DNA nanotechnology and the DNA origami technique, in particular, have provided a range of spatially addressable two- and three-dimensional nanostructures. These structures are, however, typically formed of tightly packed parallel helices. The development of wireframe structures should allow the creation of novel designs with unique functionalities, but engineering complex wireframe architectures with arbitrarily designed connections between selected vertices in three-dimensional space remains a challenge. Here, we report a design strategy for fabricating finite-size wireframe DNA nanostructures with high complexity and programmability. In our approach, the vertices are represented by n×4 multi-arm junctions (n=2-10) with controlled angles, and the lines are represented by antiparallel DNA crossover tiles of variable lengths. Scaffold strands are used to integrate the vertices and lines into fully assembled structures displaying intricate architectures. To demonstrate the versatility of the technique, a series of two-dimensional designs including quasi-crystalline patterns and curvilinear arrays or variable curvatures, and three-dimensional designs including a complex snub cube and a reconfigurable Archimedean solid were constructed.

AB - Structural DNA nanotechnology and the DNA origami technique, in particular, have provided a range of spatially addressable two- and three-dimensional nanostructures. These structures are, however, typically formed of tightly packed parallel helices. The development of wireframe structures should allow the creation of novel designs with unique functionalities, but engineering complex wireframe architectures with arbitrarily designed connections between selected vertices in three-dimensional space remains a challenge. Here, we report a design strategy for fabricating finite-size wireframe DNA nanostructures with high complexity and programmability. In our approach, the vertices are represented by n×4 multi-arm junctions (n=2-10) with controlled angles, and the lines are represented by antiparallel DNA crossover tiles of variable lengths. Scaffold strands are used to integrate the vertices and lines into fully assembled structures displaying intricate architectures. To demonstrate the versatility of the technique, a series of two-dimensional designs including quasi-crystalline patterns and curvilinear arrays or variable curvatures, and three-dimensional designs including a complex snub cube and a reconfigurable Archimedean solid were constructed.

UR - http://www.scopus.com/inward/record.url?scp=84941079426&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84941079426&partnerID=8YFLogxK

U2 - 10.1038/nnano.2015.162

DO - 10.1038/nnano.2015.162

M3 - Article

VL - 10

SP - 779

EP - 784

JO - Nature Nanotechnology

JF - Nature Nanotechnology

SN - 1748-3387

IS - 9

ER -