Complement component C1q activity and ascorbic acid nutriture in guinea pigs

B. E. Haskell; C. S. Johnston

doi:10.1093/ajcn/54.6.1228s

Complement component C1q activity and ascorbic acid nutriture in guinea pigs

B. E. Haskell, C. S. Johnston

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

When guinea pigs are fed tissue-saturating amounts of ascorbate, C1q concentrations are significantly higher than in those animals fed only enough ascorbate for adequate growth and for the prevention of scurvy. C1q is the recognition protein of the classical complement pathway, a system of blood proteins that constitutes an important part of host defense against pathogens. The observed effect of ascorbate nutriture on C1q concentrations is consistent with the known role of ascorbic acid in hydroxyproline biosynthesis. C1q is a hydroxyproline-containing protein with structural similarities to collagen.

Original language	English (US)
Pages (from-to)	1228S-1230S
Journal	American Journal of Clinical Nutrition
Volume	54
Issue number	6 SUPPL.
DOIs	https://doi.org/10.1093/ajcn/54.6.1228s
State	Published - 1991
Externally published	Yes

Keywords

Ascorbic acid
C1q
Complement
Hydroxyproline

ASJC Scopus subject areas

Medicine (miscellaneous)
Nutrition and Dietetics

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10.1093/ajcn/54.6.1228s

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title = "Complement component C1q activity and ascorbic acid nutriture in guinea pigs",

abstract = "When guinea pigs are fed tissue-saturating amounts of ascorbate, C1q concentrations are significantly higher than in those animals fed only enough ascorbate for adequate growth and for the prevention of scurvy. C1q is the recognition protein of the classical complement pathway, a system of blood proteins that constitutes an important part of host defense against pathogens. The observed effect of ascorbate nutriture on C1q concentrations is consistent with the known role of ascorbic acid in hydroxyproline biosynthesis. C1q is a hydroxyproline-containing protein with structural similarities to collagen.",

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year = "1991",

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pages = "1228S--1230S",

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T1 - Complement component C1q activity and ascorbic acid nutriture in guinea pigs

AU - Haskell, B. E.

AU - Johnston, C. S.

PY - 1991

Y1 - 1991

N2 - When guinea pigs are fed tissue-saturating amounts of ascorbate, C1q concentrations are significantly higher than in those animals fed only enough ascorbate for adequate growth and for the prevention of scurvy. C1q is the recognition protein of the classical complement pathway, a system of blood proteins that constitutes an important part of host defense against pathogens. The observed effect of ascorbate nutriture on C1q concentrations is consistent with the known role of ascorbic acid in hydroxyproline biosynthesis. C1q is a hydroxyproline-containing protein with structural similarities to collagen.

AB - When guinea pigs are fed tissue-saturating amounts of ascorbate, C1q concentrations are significantly higher than in those animals fed only enough ascorbate for adequate growth and for the prevention of scurvy. C1q is the recognition protein of the classical complement pathway, a system of blood proteins that constitutes an important part of host defense against pathogens. The observed effect of ascorbate nutriture on C1q concentrations is consistent with the known role of ascorbic acid in hydroxyproline biosynthesis. C1q is a hydroxyproline-containing protein with structural similarities to collagen.

KW - Ascorbic acid

KW - C1q

KW - Complement

KW - Hydroxyproline

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AN - SCOPUS:0025880862

SN - 0002-9165

VL - 54

SP - 1228S-1230S

JO - American Journal of Clinical Nutrition

JF - American Journal of Clinical Nutrition

IS - 6 SUPPL.

ER -

Complement component C1q activity and ascorbic acid nutriture in guinea pigs

Abstract

Keywords

ASJC Scopus subject areas

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