Complement component C1q activity and ascorbic acid nutriture in guinea pigs

B. E. Haskell, Carol Johnston

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

When guinea pigs are fed tissue-saturating amounts of ascorbate, C1q concentrations are significantly higher than in those animals fed only enough ascorbate for adequate growth and for the prevention of scurvy. C1q is the recognition protein of the classical complement pathway, a system of blood proteins that constitutes an important part of host defense against pathogens. The observed effect of ascorbate nutriture on C1q concentrations is consistent with the known role of ascorbic acid in hydroxyproline biosynthesis. C1q is a hydroxyproline-containing protein with structural similarities to collagen.

Original languageEnglish (US)
JournalAmerican Journal of Clinical Nutrition
Volume54
Issue number6 SUPPL.
StatePublished - 1991
Externally publishedYes

Fingerprint

Complement C1q
hydroxyproline
Hydroxyproline
guinea pigs
Ascorbic Acid
Guinea Pigs
complement
ascorbic acid
scurvy
Scurvy
Classical Complement Pathway
blood proteins
collagen
Blood Proteins
Proteins
Collagen
proteins
biosynthesis
pathogens
Growth

Keywords

  • Ascorbic acid
  • C1q
  • Complement
  • Hydroxyproline

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)

Cite this

Complement component C1q activity and ascorbic acid nutriture in guinea pigs. / Haskell, B. E.; Johnston, Carol.

In: American Journal of Clinical Nutrition, Vol. 54, No. 6 SUPPL., 1991.

Research output: Contribution to journalArticle

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