Comparison of two blood pool contrast agents for 0.5-T MR angiography: Experimental study in rabbits

Sharon E. Clarke, Hanns Joachim Weinmann, Erbin Dai, Alexandra R. Lucas, Brian K. Rutt

Research output: Contribution to journalArticlepeer-review

49 Scopus citations

Abstract

PURPOSE: To evaluate two experimental blood pool agents for potential use in equilibrium phase abdominal magnetic resonance (MR) angiography. MATERIALS AND METHODS: MR imaging at 0.5 T was performed in 37 rabbits before and after intravenous injection of a gadolinium-based blood pool contrast agent (SH L 643 A), superparamagnetic iron oxide blood pool agent (SH U 555 C), or gadopentetate dimeglumine. T1-weighted fast spoiled gradient-echo images from the renal arteries to below the iliac bifurcation were obtained. The aorta-to-tissue signal difference-to-noise ratio (SDNR) was measured over time. RESULTS: Both blood pool agents yielded excellent demonstration of the rabbit abdominal aorta. At a dose of 0.1 mmol/kg, both provided a statistically significant increase in aorta-to-tissue SDNR in comparison with that achieved with gadopentetate dimeglumine (200% increase for SH L 643 A, 95% increase for SH U 555 C; P < .05). A 0.1 mmol/kg dose of SH L 643 A provided a 24% increase in SDNR relative to the increase with a 0.37 mmol/kg dose of gadopentetate dimeglumine. Time-dependent enhancement properties of the blood pool agents differed due to differences in elimination method. CONCLUSION: Both blood pool agents were found to be promising contrast agents for 0.5-T MR angiography; however, their clinical applicability warrants further investigation. The gadolinium-based agent had several advantages over the iron oxide compound, including less T2* dephasing, lack of susceptibility artifacts, and fast renal elimination.

Original languageEnglish (US)
Pages (from-to)787-794
Number of pages8
JournalRadiology
Volume214
Issue number3
DOIs
StatePublished - Mar 2000
Externally publishedYes

Keywords

  • Contrast media, comparative studies
  • Contrast media, experimental studies
  • Gadolinium
  • Iron
  • Magnetic resonance (MR), contrast media
  • Magnetic resonance (MR), vascular studies

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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