Comparison of Human and Animal Surveillance Data for H5N1 Influenza A in Egypt 2006-2011

Peter M. Rabinowitz, Deron Galusha, Sally Vegso, Jennifer Michalove, Seppo Rinne, Matthew Scotch, Michael Kane

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Background: The majority of emerging infectious diseases are zoonotic (transmissible between animals and humans) in origin, and therefore integrated surveillance of disease events in humans and animals has been recommended to support effective global response to disease emergence. While in the past decade there has been extensive global surveillance for highly pathogenic avian influenza (HPAI) infection in both animals and humans, there have been few attempts to compare these data streams and evaluate the utility of such integration. Methodology: We compared reports of bird outbreaks of HPAI H5N1 in Egypt for 2006-2011 compiled by the World Organisation for Animal Health (OIE) and the UN Food and Agriculture Organization (FAO) EMPRESi reporting system with confirmed human H5N1 cases reported to the World Health Organization (WHO) for Egypt during the same time period. Principal Findings: Both human cases and bird outbreaks showed a cyclic pattern for the country as a whole, and there was a statistically significant temporal correlation between the data streams. At the governorate level, the first outbreak in birds in a season usually but not always preceded the first human case, and the time lag between events varied widely, suggesting regional differences in zoonotic risk and/or surveillance effectiveness. In a multivariate risk model, lower temperature, lower urbanization, higher poultry density, and the recent occurrence of a bird outbreak were associated with increased risk of a human case of HPAI in the same governorate, although the positive predictive value of a bird outbreak was low. Conclusions: Integrating data streams of surveillance for human and animal cases of zoonotic disease holds promise for better prediction of disease risk and identification of environmental and regional factors that can affect risk. Such efforts can also point out gaps in human and animal surveillance systems and generate hypotheses regarding disease transmission.

Original languageEnglish (US)
Article numbere43851
JournalPLoS One
Volume7
Issue number9
DOIs
StatePublished - Sep 27 2012

Fingerprint

Egypt
influenza
Human Influenza
Birds
Animals
monitoring
Disease Outbreaks
animals
Influenza in Birds
Zoonoses
avian influenza
birds
Health
Poultry
Emerging Communicable Diseases
Agriculture
Food and Agriculture Organization
Urbanization
disease surveillance
emerging diseases

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Rabinowitz, P. M., Galusha, D., Vegso, S., Michalove, J., Rinne, S., Scotch, M., & Kane, M. (2012). Comparison of Human and Animal Surveillance Data for H5N1 Influenza A in Egypt 2006-2011. PLoS One, 7(9), [e43851]. https://doi.org/10.1371/journal.pone.0043851

Comparison of Human and Animal Surveillance Data for H5N1 Influenza A in Egypt 2006-2011. / Rabinowitz, Peter M.; Galusha, Deron; Vegso, Sally; Michalove, Jennifer; Rinne, Seppo; Scotch, Matthew; Kane, Michael.

In: PLoS One, Vol. 7, No. 9, e43851, 27.09.2012.

Research output: Contribution to journalArticle

Rabinowitz, PM, Galusha, D, Vegso, S, Michalove, J, Rinne, S, Scotch, M & Kane, M 2012, 'Comparison of Human and Animal Surveillance Data for H5N1 Influenza A in Egypt 2006-2011', PLoS One, vol. 7, no. 9, e43851. https://doi.org/10.1371/journal.pone.0043851
Rabinowitz, Peter M. ; Galusha, Deron ; Vegso, Sally ; Michalove, Jennifer ; Rinne, Seppo ; Scotch, Matthew ; Kane, Michael. / Comparison of Human and Animal Surveillance Data for H5N1 Influenza A in Egypt 2006-2011. In: PLoS One. 2012 ; Vol. 7, No. 9.
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