Comparison of Bladder Carcinogens in the Urine of E-cigarette Users Versus Non E-cigarette Using Controls

Thomas W. Fuller, Abhinav P. Acharya, Thiagarajan Meyyappan, Michelle Yu, Godugu Bhaskar, Steven R. Little, Tatum V. Tarin

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Electronic cigarette (EC) use is gaining popularity as a substitute for conventional smoking due to the perception and evidence it represents a safer alternative. In contrast to the common perception amongst users that ECs represent no risk initial studies have revealed a complex composition of e-cigarette liquids. Conventional cigarette smoking is a known risk factor for developing bladder cancer and prior reports raise concern some of those causative compounds may exist in EC liquids or vapor. Urine samples were collected from 13 e-cigarette using subjects and 10 non e-cigarette using controls. Five known bladder carcinogens that are either present in conventional cigarettes, products of combustion, or solvents believed to be used in some e-cigarette formulations were quantified by liquid chromatography - mass spectrometry (LC-MS). Analysis of e-cigarette user urine revealed the presence of two carcinogenic compounds, o-toluidine and 2-naphthylamine, at a mean 2.3 and 1.3 fold higher concentration (p-value of 0.0013 and 0.014 respectively). Many of these subjects (9/13) were long term nonsmokers (>12 months). Further study is needed to clarify the safety profile of e-cigarettes and their contribution to the development of bladder cancer given the greater concentration of carcinogenic aromatic amines in the urine of e-cigarette users.

Original languageEnglish (US)
Article number507
JournalScientific reports
Volume8
Issue number1
DOIs
StatePublished - Dec 1 2018
Externally publishedYes

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Tobacco Products
Carcinogens
Urinary Bladder
Urine
2-toluidine
Urinary Bladder Neoplasms
2-Naphthylamine
Smoking
Electronic Cigarettes
Liquid Chromatography
Amines
Mass Spectrometry
Safety

ASJC Scopus subject areas

  • General

Cite this

Comparison of Bladder Carcinogens in the Urine of E-cigarette Users Versus Non E-cigarette Using Controls. / Fuller, Thomas W.; Acharya, Abhinav P.; Meyyappan, Thiagarajan; Yu, Michelle; Bhaskar, Godugu; Little, Steven R.; Tarin, Tatum V.

In: Scientific reports, Vol. 8, No. 1, 507, 01.12.2018.

Research output: Contribution to journalArticle

Fuller, Thomas W. ; Acharya, Abhinav P. ; Meyyappan, Thiagarajan ; Yu, Michelle ; Bhaskar, Godugu ; Little, Steven R. ; Tarin, Tatum V. / Comparison of Bladder Carcinogens in the Urine of E-cigarette Users Versus Non E-cigarette Using Controls. In: Scientific reports. 2018 ; Vol. 8, No. 1.
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