Abstract
Vascular smooth muscle cell (VSMC) proliferation and migration has been correlated with intimal hyperplasia (IH) after vascular interventions such as angioplasty, stenting, and vascular graft surgery. Therefore, therapies targeting inhibition of VSMC migration may lead to higher patency rates in vascular grafts and reduced IH in other vascular interventions. This study attempts to understand the relationship with a vβ 3 and Arg-Gly-Asp (RGD) integrin-ligand affinity and cell population migration. Surfaces are modified with Linear GRGDSP, Cyclic GPenGRGDSPCA, and negative control GRADSP. Culture dish polystyrene and YIGSR were also compared. Areas containing VSMC populations expanded over four days. At the end of 96 hours, Linear-RGD, cyclic-RGD, neg-GRAD, YIGSR, and plastic control increased area ratio by 1.22 ± 0.04, 1.19 ± 0.11, 1.10 ± 0.20, 1.18 ± 0.10 and 1.13 ± 0.01, respectively.
| Original language | English (US) |
|---|---|
| Title of host publication | Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings |
| Pages | 576-577 |
| Number of pages | 2 |
| Volume | 1 |
| State | Published - 2002 |
| Event | Proceedings of the 2002 IEEE Engineering in Medicine and Biology 24th Annual Conference and the 2002 Fall Meeting of the Biomedical Engineering Society (BMES / EMBS) - Houston, TX, United States Duration: Oct 23 2002 → Oct 26 2002 |
Other
| Other | Proceedings of the 2002 IEEE Engineering in Medicine and Biology 24th Annual Conference and the 2002 Fall Meeting of the Biomedical Engineering Society (BMES / EMBS) |
|---|---|
| Country/Territory | United States |
| City | Houston, TX |
| Period | 10/23/02 → 10/26/02 |
Keywords
- Hyperplasia
- Integrin
- Migration
- Peptide
- Proliferation
- Smooth muscle cells
ASJC Scopus subject areas
- Bioengineering