Comparing vascular smooth muscle cell population migration on various surface chemistry modifications

C. E. Kennedy; G. R. Ehteshami; Stephen Massia

Comparing vascular smooth muscle cell population migration on various surface chemistry modifications

C. E. Kennedy, G. R. Ehteshami, Stephen Massia

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Vascular smooth muscle cell (VSMC) proliferation and migration has been correlated with intimal hyperplasia (IH) after vascular interventions such as angioplasty, stenting, and vascular graft surgery. Therefore, therapies targeting inhibition of VSMC migration may lead to higher patency rates in vascular grafts and reduced IH in other vascular interventions. This study attempts to understand the relationship with a _vβ ₃ and Arg-Gly-Asp (RGD) integrin-ligand affinity and cell population migration. Surfaces are modified with Linear GRGDSP, Cyclic GPenGRGDSPCA, and negative control GRADSP. Culture dish polystyrene and YIGSR were also compared. Areas containing VSMC populations expanded over four days. At the end of 96 hours, Linear-RGD, cyclic-RGD, neg-GRAD, YIGSR, and plastic control increased area ratio by 1.22 ± 0.04, 1.19 ± 0.11, 1.10 ± 0.20, 1.18 ± 0.10 and 1.13 ± 0.01, respectively.

Original language	English (US)
Title of host publication	Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Pages	576-577
Number of pages	2
Volume	1
State	Published - 2002
Event	Proceedings of the 2002 IEEE Engineering in Medicine and Biology 24th Annual Conference and the 2002 Fall Meeting of the Biomedical Engineering Society (BMES / EMBS) - Houston, TX, United States Duration: Oct 23 2002 → Oct 26 2002

Other

Other	Proceedings of the 2002 IEEE Engineering in Medicine and Biology 24th Annual Conference and the 2002 Fall Meeting of the Biomedical Engineering Society (BMES / EMBS)
Country	United States
City	Houston, TX
Period	10/23/02 → 10/26/02

Keywords

Hyperplasia
Integrin
Migration
Peptide
Proliferation
Smooth muscle cells

ASJC Scopus subject areas

Bioengineering

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Cite this

Kennedy, CE, Ehteshami, GR & Massia, S 2002, Comparing vascular smooth muscle cell population migration on various surface chemistry modifications. in Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. vol. 1, pp. 576-577, Proceedings of the 2002 IEEE Engineering in Medicine and Biology 24th Annual Conference and the 2002 Fall Meeting of the Biomedical Engineering Society (BMES / EMBS), Houston, TX, United States, 10/23/02.

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title = "Comparing vascular smooth muscle cell population migration on various surface chemistry modifications",

abstract = "Vascular smooth muscle cell (VSMC) proliferation and migration has been correlated with intimal hyperplasia (IH) after vascular interventions such as angioplasty, stenting, and vascular graft surgery. Therefore, therapies targeting inhibition of VSMC migration may lead to higher patency rates in vascular grafts and reduced IH in other vascular interventions. This study attempts to understand the relationship with a vβ 3 and Arg-Gly-Asp (RGD) integrin-ligand affinity and cell population migration. Surfaces are modified with Linear GRGDSP, Cyclic GPenGRGDSPCA, and negative control GRADSP. Culture dish polystyrene and YIGSR were also compared. Areas containing VSMC populations expanded over four days. At the end of 96 hours, Linear-RGD, cyclic-RGD, neg-GRAD, YIGSR, and plastic control increased area ratio by 1.22 ± 0.04, 1.19 ± 0.11, 1.10 ± 0.20, 1.18 ± 0.10 and 1.13 ± 0.01, respectively. ",

keywords = "Hyperplasia, Integrin, Migration, Peptide, Proliferation, Smooth muscle cells",

author = "Kennedy, {C. E.} and Ehteshami, {G. R.} and Stephen Massia",

year = "2002",

language = "English (US)",

volume = "1",

pages = "576--577",

booktitle = "Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings",

note = "Proceedings of the 2002 IEEE Engineering in Medicine and Biology 24th Annual Conference and the 2002 Fall Meeting of the Biomedical Engineering Society (BMES / EMBS) ; Conference date: 23-10-2002 Through 26-10-2002",

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T1 - Comparing vascular smooth muscle cell population migration on various surface chemistry modifications

AU - Kennedy, C. E.

AU - Ehteshami, G. R.

AU - Massia, Stephen

PY - 2002

Y1 - 2002

N2 - Vascular smooth muscle cell (VSMC) proliferation and migration has been correlated with intimal hyperplasia (IH) after vascular interventions such as angioplasty, stenting, and vascular graft surgery. Therefore, therapies targeting inhibition of VSMC migration may lead to higher patency rates in vascular grafts and reduced IH in other vascular interventions. This study attempts to understand the relationship with a vβ 3 and Arg-Gly-Asp (RGD) integrin-ligand affinity and cell population migration. Surfaces are modified with Linear GRGDSP, Cyclic GPenGRGDSPCA, and negative control GRADSP. Culture dish polystyrene and YIGSR were also compared. Areas containing VSMC populations expanded over four days. At the end of 96 hours, Linear-RGD, cyclic-RGD, neg-GRAD, YIGSR, and plastic control increased area ratio by 1.22 ± 0.04, 1.19 ± 0.11, 1.10 ± 0.20, 1.18 ± 0.10 and 1.13 ± 0.01, respectively.

AB - Vascular smooth muscle cell (VSMC) proliferation and migration has been correlated with intimal hyperplasia (IH) after vascular interventions such as angioplasty, stenting, and vascular graft surgery. Therefore, therapies targeting inhibition of VSMC migration may lead to higher patency rates in vascular grafts and reduced IH in other vascular interventions. This study attempts to understand the relationship with a vβ 3 and Arg-Gly-Asp (RGD) integrin-ligand affinity and cell population migration. Surfaces are modified with Linear GRGDSP, Cyclic GPenGRGDSPCA, and negative control GRADSP. Culture dish polystyrene and YIGSR were also compared. Areas containing VSMC populations expanded over four days. At the end of 96 hours, Linear-RGD, cyclic-RGD, neg-GRAD, YIGSR, and plastic control increased area ratio by 1.22 ± 0.04, 1.19 ± 0.11, 1.10 ± 0.20, 1.18 ± 0.10 and 1.13 ± 0.01, respectively.

KW - Hyperplasia

KW - Integrin

KW - Migration

KW - Peptide

KW - Proliferation

KW - Smooth muscle cells

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