Comparing vascular smooth muscle cell population migration on various surface chemistry modifications

C. E. Kennedy, G. R. Ehteshami, Stephen Massia

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Vascular smooth muscle cell (VSMC) proliferation and migration has been correlated with intimal hyperplasia (IH) after vascular interventions such as angioplasty, stenting, and vascular graft surgery. Therefore, therapies targeting inhibition of VSMC migration may lead to higher patency rates in vascular grafts and reduced IH in other vascular interventions. This study attempts to understand the relationship with a vβ 3 and Arg-Gly-Asp (RGD) integrin-ligand affinity and cell population migration. Surfaces are modified with Linear GRGDSP, Cyclic GPenGRGDSPCA, and negative control GRADSP. Culture dish polystyrene and YIGSR were also compared. Areas containing VSMC populations expanded over four days. At the end of 96 hours, Linear-RGD, cyclic-RGD, neg-GRAD, YIGSR, and plastic control increased area ratio by 1.22 ± 0.04, 1.19 ± 0.11, 1.10 ± 0.20, 1.18 ± 0.10 and 1.13 ± 0.01, respectively.

Original languageEnglish (US)
Title of host publicationAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Pages576-577
Number of pages2
Volume1
StatePublished - 2002
EventProceedings of the 2002 IEEE Engineering in Medicine and Biology 24th Annual Conference and the 2002 Fall Meeting of the Biomedical Engineering Society (BMES / EMBS) - Houston, TX, United States
Duration: Oct 23 2002Oct 26 2002

Other

OtherProceedings of the 2002 IEEE Engineering in Medicine and Biology 24th Annual Conference and the 2002 Fall Meeting of the Biomedical Engineering Society (BMES / EMBS)
CountryUnited States
CityHouston, TX
Period10/23/0210/26/02

Keywords

  • Hyperplasia
  • Integrin
  • Migration
  • Peptide
  • Proliferation
  • Smooth muscle cells

ASJC Scopus subject areas

  • Bioengineering

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  • Cite this

    Kennedy, C. E., Ehteshami, G. R., & Massia, S. (2002). Comparing vascular smooth muscle cell population migration on various surface chemistry modifications. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings (Vol. 1, pp. 576-577)