Comparing glycemic indicators of prediabetes

A prospective study of obese Latino Youth

Joon Young Kim, Michael I. Goran, Claudia M. Toledo-Corral, Marc J. Weigensberg, Gabriel Shaibi

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objective: One hour (1-hr) glucose during an oral glucose tolerance test (OGTT) is an emerging biomarker for type 2 diabetes. We compared the predictive power of 1-hr glucose to traditional glycemic markers for prospectively identifying prediabetes in youth. Research design and methods: Obese normoglycemic Latino youth (N = 116) were assessed at baseline for glycated hemoglobin (HbA1c), fasting, 1-hr, and 2-hr glucose during an OGTT and were followed for up to 8 yr for the development of prediabetes. Receiver operating characteristic (ROC) curves were used and a multivariable prediction model was developed. Results: The area under the 1-hr glucose ROC curve was the most powerful predictor of prediabetes over time [0.73, 95% confidence interval (CI) = 0.64-0.83]. However, combining all indicators into a single model was superior to individual marker models (0.77, 95% CI = 0.690.86). Conclusions: These results further support the utility of 1-hr glucose during an OGTT as a prospective marker of diabetes risk in youth.

Original languageEnglish (US)
Pages (from-to)640-643
Number of pages4
JournalPediatric Diabetes
Volume16
Issue number8
DOIs
StatePublished - Dec 1 2015

Fingerprint

Prediabetic State
Hispanic Americans
Prospective Studies
Glucose
Glucose Tolerance Test
ROC Curve
Confidence Intervals
Glycosylated Hemoglobin A
Type 2 Diabetes Mellitus
Fasting
Research Design
Biomarkers

Keywords

  • 1-hr glucose
  • Pediatrics
  • Prediabetes
  • Receiver operating characteristic curve

ASJC Scopus subject areas

  • Internal Medicine
  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism

Cite this

Comparing glycemic indicators of prediabetes : A prospective study of obese Latino Youth. / Kim, Joon Young; Goran, Michael I.; Toledo-Corral, Claudia M.; Weigensberg, Marc J.; Shaibi, Gabriel.

In: Pediatric Diabetes, Vol. 16, No. 8, 01.12.2015, p. 640-643.

Research output: Contribution to journalArticle

Kim, Joon Young ; Goran, Michael I. ; Toledo-Corral, Claudia M. ; Weigensberg, Marc J. ; Shaibi, Gabriel. / Comparing glycemic indicators of prediabetes : A prospective study of obese Latino Youth. In: Pediatric Diabetes. 2015 ; Vol. 16, No. 8. pp. 640-643.
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