Comparative analyses reveal a complex history of molecular evolution for human MYH16

George H. Perry, Brian C. Verrelli, Anne Stone

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

We describe the pattern of molecular evolution at a sarcomeric myosin gene, MYH16, using more than 30,000 bp of exon and intron sequence data from the chimpanzee and human genome sequencing projects to evaluate the timing and consequences of a human lineage-specific frameshift deletion. We estimate the age of the deletion at approximately 5.3 MYA. This estimate is consistent with the time of human and chimpanzee divergence and is significantly older than the first appearance of the genus Homo in the fossil record. We also find conflicting estimates of nonsynonymous fixation rates (dN) across different regions of this gene, revealing a complex pattern inconsistent with a simple model of pseudogene evolution for human MYH16.

Original languageEnglish (US)
Pages (from-to)379-382
Number of pages4
JournalMolecular Biology and Evolution
Volume22
Issue number3
DOIs
StatePublished - Mar 2005

Fingerprint

Molecular Evolution
Pan troglodytes
Genes
gene
history
fossil record
Human Genome Project
fixation
Pseudogenes
Fossils
genome
divergence
Hominidae
Myosins
Introns
pseudogenes
Exons
Homo
myosin
exons

Keywords

  • Macaca mulatta
  • MYH16
  • Pan troglodytes
  • Sarcomeric myosin

ASJC Scopus subject areas

  • Genetics
  • Biochemistry
  • Genetics(clinical)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Ecology, Evolution, Behavior and Systematics
  • Agricultural and Biological Sciences (miscellaneous)
  • Molecular Biology

Cite this

Comparative analyses reveal a complex history of molecular evolution for human MYH16. / Perry, George H.; Verrelli, Brian C.; Stone, Anne.

In: Molecular Biology and Evolution, Vol. 22, No. 3, 03.2005, p. 379-382.

Research output: Contribution to journalArticle

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