Combining sperm typing and linkage disequilibrium analyses reveals differences in selective pressures or recombination rates across human populations

Vanessa J. Clark, Susan E. Ptak, Irene Tiemann, Yudong Qian, Graham Coop, Anne Stone, Molly Przeworski, Norman Arnheim, Anna Di Rienzo

Research output: Contribution to journalArticle

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Abstract

A previous polymorphism survey of the type 2 diabetes gene CAPN10 identified a segment showing an excess of polymorphism levels in all population samples, coinciding with localized breakdown of linkage disequilibrium (LD) in a sample of Hausa from Cameroon, but not in non-African samples. This raised the possibility that a recombination hotspot is present in all populations and we had insufficient power to detect it in the non-African data. To test this possibility, we estimated the crossover rate by sperm typing in five non-African men; these estimates were consistent with the LD decay in the non-African, but not in the Hausa data. Moreover, resequencing the orthologous region in a sample of Western chimpanzees did not show either an excess of polymorphism level or rapid LD decay, suggesting that the processes underlying the patterns observed in humans operated only on the human lineage. These results suggest that a hotspot of recombination has recently arisen in humans and has reached higher frequency in the Hausa than in non-Africans, or that there is no elevation in crossover rate in any human population, and the observed variation results from long-standing balancing selection.

Original languageEnglish (US)
Pages (from-to)795-804
Number of pages10
JournalGenetics
Volume175
Issue number2
DOIs
StatePublished - Feb 2007

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Linkage Disequilibrium
Genetic Recombination
Spermatozoa
Population
Cameroon
Pan troglodytes
Type 2 Diabetes Mellitus
Genes

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

Combining sperm typing and linkage disequilibrium analyses reveals differences in selective pressures or recombination rates across human populations. / Clark, Vanessa J.; Ptak, Susan E.; Tiemann, Irene; Qian, Yudong; Coop, Graham; Stone, Anne; Przeworski, Molly; Arnheim, Norman; Di Rienzo, Anna.

In: Genetics, Vol. 175, No. 2, 02.2007, p. 795-804.

Research output: Contribution to journalArticle

Clark, Vanessa J. ; Ptak, Susan E. ; Tiemann, Irene ; Qian, Yudong ; Coop, Graham ; Stone, Anne ; Przeworski, Molly ; Arnheim, Norman ; Di Rienzo, Anna. / Combining sperm typing and linkage disequilibrium analyses reveals differences in selective pressures or recombination rates across human populations. In: Genetics. 2007 ; Vol. 175, No. 2. pp. 795-804.
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