Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2

Rajnish A. Gupta; Raymond N. DuBois

doi:10.1038/35094017

Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2

Rajnish A. Gupta, Raymond N. DuBois

Research output: Contribution to journal › Article › peer-review

970 Scopus citations

Abstract

Population-based studies have established that long-term intake of non-steroidal anti-inflammatory drugs (NSAIDs), compounds that inhibit the enzymatic activity of cyclooxygenase (COX), reduces the relative risk for developing colorectal cancer. These studies led to the identification of a molecular target, COX-2, that is involved in tumour promotion during colorectal cancer progression. Recent studies in humans indicate that therapy with specific COX-2 inhibitors might be an effective approach to colorectal cancer prevention and treatment.

Original language	English (US)
Pages (from-to)	11-21
Number of pages	11
Journal	Nature Reviews Cancer
Volume	1
Issue number	1
DOIs	https://doi.org/10.1038/35094017
State	Published - Jan 1 2001

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1038/35094017

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Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2

Abstract

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