Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2

Rajnish A. Gupta, Raymond N. DuBois

    Research output: Contribution to journalArticlepeer-review

    918 Scopus citations

    Abstract

    Population-based studies have established that long-term intake of non-steroidal anti-inflammatory drugs (NSAIDs), compounds that inhibit the enzymatic activity of cyclooxygenase (COX), reduces the relative risk for developing colorectal cancer. These studies led to the identification of a molecular target, COX-2, that is involved in tumour promotion during colorectal cancer progression. Recent studies in humans indicate that therapy with specific COX-2 inhibitors might be an effective approach to colorectal cancer prevention and treatment.

    Original languageEnglish (US)
    Pages (from-to)11-21
    Number of pages11
    JournalNature Reviews Cancer
    Volume1
    Issue number1
    DOIs
    StatePublished - Jan 1 2001

    ASJC Scopus subject areas

    • Oncology
    • Cancer Research

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