Co-localization of PKCε with various GABA(A) receptor subunits in the mouse limbic system

M. F. Olive, Clyde W. Hodge

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

The distribution of PKCε and its co-localization with various GABA(A) receptor subunits within limbic structures of the mouse brain was examined by fluorescence immunohistochemistry. Levels of PKCε immunoreactivity were highest in the cingulate cortex and moderate in the nucleus accumbens, and lowest in the prelimbic-cortex and basolateral amygdala. Co-localization of PKCε immunoreactivity with the GABA(A) receptor, α12/a, and 72 subunits varied by subunit and brain region examined, with the majority of co- localization occuring in the dentate gyrus, nucleus accumbens and basolateral amygdala. These results demonstrate that PKCε may interact with GABA(A) receptors in a subunit and region, specific manner, and provide a potential anatomical basis for recent behavioral and biochemical evidence that PKCε modulates GABA(A) receptor function. (C) 2000 Lippincott Williams and Wilkins.

Original languageEnglish (US)
Pages (from-to)683-687
Number of pages5
JournalNeuroReport
Volume11
Issue number4
DOIs
StatePublished - Mar 20 2000
Externally publishedYes

Keywords

  • Basolateral amygdala
  • Cingulate cortex
  • Dentate gyrus
  • Epsilon
  • GABA
  • Limbic system
  • Nucleus accumbens
  • Prelimbic cortex
  • Protein kinase C
  • Receptor

ASJC Scopus subject areas

  • Neuroscience(all)

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