Abstract
The distribution of PKCε and its co-localization with various GABA(A) receptor subunits within limbic structures of the mouse brain was examined by fluorescence immunohistochemistry. Levels of PKCε immunoreactivity were highest in the cingulate cortex and moderate in the nucleus accumbens, and lowest in the prelimbic-cortex and basolateral amygdala. Co-localization of PKCε immunoreactivity with the GABA(A) receptor, α12/a, and 72 subunits varied by subunit and brain region examined, with the majority of co- localization occuring in the dentate gyrus, nucleus accumbens and basolateral amygdala. These results demonstrate that PKCε may interact with GABA(A) receptors in a subunit and region, specific manner, and provide a potential anatomical basis for recent behavioral and biochemical evidence that PKCε modulates GABA(A) receptor function. (C) 2000 Lippincott Williams and Wilkins.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 683-687 |
| Number of pages | 5 |
| Journal | NeuroReport |
| Volume | 11 |
| Issue number | 4 |
| DOIs | |
| State | Published - Mar 20 2000 |
| Externally published | Yes |
Keywords
- Basolateral amygdala
- Cingulate cortex
- Dentate gyrus
- Epsilon
- GABA
- Limbic system
- Nucleus accumbens
- Prelimbic cortex
- Protein kinase C
- Receptor
ASJC Scopus subject areas
- General Neuroscience