CMOS readout and control architecture for single-cell real-time microsystems

Diego Barrettino, Barry Lutz, Maria Elena Martin, Sarah McQuaide, Deirdre Meldrum

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This paper presents a readout and control architecture for single-cell real-time microsystems. The singlecell microsystem comprises 0.35-μm CMOS electronics combined with post-CMOS processing to form a microhotplate and Platinum (Pt) electrodes, and a polymethyl methacrylate (PMMA) microfluidic device to form the microchannel. The on-chip electronics can measure cell parameters such as rate of cell respiration, cell size, membrane capacitance, and cytoplasm resistance. Further, the on-chip electronics can control the microchannel temperature to quantify single-cell messenger RNA (mRNA) for gene expression by quantitative Reverse Transcriptase-Polymerase Chain Reaction (qRTPCR). The chip communication is handled with an I 2C digital standard interface.

Original languageEnglish (US)
Title of host publicationProceedings - IEEE International Symposium on Circuits and Systems
Pages4795-4798
Number of pages4
DOIs
StatePublished - 2005
Externally publishedYes
EventIEEE International Symposium on Circuits and Systems 2005, ISCAS 2005 - Kobe, Japan
Duration: May 23 2005May 26 2005

Other

OtherIEEE International Symposium on Circuits and Systems 2005, ISCAS 2005
CountryJapan
CityKobe
Period5/23/055/26/05

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ASJC Scopus subject areas

  • Electrical and Electronic Engineering

Cite this

Barrettino, D., Lutz, B., Martin, M. E., McQuaide, S., & Meldrum, D. (2005). CMOS readout and control architecture for single-cell real-time microsystems. In Proceedings - IEEE International Symposium on Circuits and Systems (pp. 4795-4798). [1465705] https://doi.org/10.1109/ISCAS.2005.1465705