Clonal polymorphism and high heterozygosity in the celibate genome of the Amazon molly

Wesley C. Warren; Raquel García-Pérez; Sen Xu; Kathrin P. Lampert; Domitille Chalopin; Matthias Stöck; Laurence Loewe; Yuan Lu; Lukas Kuderna; Patrick Minx; Michael J. Montague; Chad Tomlinson; Ladeana W. Hillier; Daniel N. Murphy; John Wang; Zhongwei Wang; Constantino Macias Garcia; Gregg C.W. Thomas; Jean Nicolas Volff; Fabiana Farias; Bronwen Aken; Ronald B. Walter; Kim D. Pruitt; Tomas Marques-Bonet; Matthew W. Hahn; Susanne Kneitz; Michael Lynch; Manfred Schartl

doi:10.1038/s41559-018-0473-y

Clonal polymorphism and high heterozygosity in the celibate genome of the Amazon molly

Wesley C. Warren, Raquel García-Pérez, Sen Xu, Kathrin P. Lampert, Domitille Chalopin, Matthias Stöck, Laurence Loewe, Yuan Lu, Lukas Kuderna, Patrick Minx, Michael J. Montague, Chad Tomlinson, Ladeana W. Hillier, Daniel N. Murphy, John Wang, Zhongwei Wang, Constantino Macias Garcia, Gregg C.W. Thomas, Jean Nicolas Volff, Fabiana FariasBronwen Aken, Ronald B. Walter, Kim D. Pruitt, Tomas Marques-Bonet, Matthew W. Hahn, Susanne Kneitz, Michael Lynch, Manfred Schartl

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88 Scopus citations

Abstract

The extreme rarity of asexual vertebrates in nature is generally explained by genomic decay due to absence of meiotic recombination, thus leading to extinction of such lineages. We explore features of a vertebrate asexual genome, the Amazon molly, Poecilia formosa, and find few signs of genetic degeneration but unique genetic variability and ongoing evolution. We uncovered a substantial clonal polymorphism and, as a conserved feature from its interspecific hybrid origin, a 10-fold higher heterozygosity than in the sexual parental species. These characteristics seem to be a principal reason for the unpredicted fitness of this asexual vertebrate. Our data suggest that asexual vertebrate lineages are scarce not because they are at a disadvantage, but because the genomic combinations required to bypass meiosis and to make up a functioning hybrid genome are rarely met in nature.

Original language	English (US)
Pages (from-to)	669-679
Number of pages	11
Journal	Nature Ecology and Evolution
Volume	2
Issue number	4
DOIs	https://doi.org/10.1038/s41559-018-0473-y
State	Published - Apr 1 2018
Externally published	Yes

ASJC Scopus subject areas

Ecology, Evolution, Behavior and Systematics
Ecology

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Warren, W. C., García-Pérez, R., Xu, S., Lampert, K. P., Chalopin, D., Stöck, M., Loewe, L., Lu, Y., Kuderna, L., Minx, P., Montague, M. J., Tomlinson, C., Hillier, L. W., Murphy, D. N., Wang, J., Wang, Z., Garcia, C. M., Thomas, G. C. W., Volff, J. N., ... Schartl, M. (2018). Clonal polymorphism and high heterozygosity in the celibate genome of the Amazon molly. Nature Ecology and Evolution, 2(4), 669-679. https://doi.org/10.1038/s41559-018-0473-y

Warren, WC, García-Pérez, R, Xu, S, Lampert, KP, Chalopin, D, Stöck, M, Loewe, L, Lu, Y, Kuderna, L, Minx, P, Montague, MJ, Tomlinson, C, Hillier, LW, Murphy, DN, Wang, J, Wang, Z, Garcia, CM, Thomas, GCW, Volff, JN, Farias, F, Aken, B, Walter, RB, Pruitt, KD, Marques-Bonet, T, Hahn, MW, Kneitz, S, Lynch, M & Schartl, M 2018, 'Clonal polymorphism and high heterozygosity in the celibate genome of the Amazon molly', Nature Ecology and Evolution, vol. 2, no. 4, pp. 669-679. https://doi.org/10.1038/s41559-018-0473-y

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abstract = "The extreme rarity of asexual vertebrates in nature is generally explained by genomic decay due to absence of meiotic recombination, thus leading to extinction of such lineages. We explore features of a vertebrate asexual genome, the Amazon molly, Poecilia formosa, and find few signs of genetic degeneration but unique genetic variability and ongoing evolution. We uncovered a substantial clonal polymorphism and, as a conserved feature from its interspecific hybrid origin, a 10-fold higher heterozygosity than in the sexual parental species. These characteristics seem to be a principal reason for the unpredicted fitness of this asexual vertebrate. Our data suggest that asexual vertebrate lineages are scarce not because they are at a disadvantage, but because the genomic combinations required to bypass meiosis and to make up a functioning hybrid genome are rarely met in nature.",

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AU - Chalopin, Domitille

AU - Stöck, Matthias

AU - Loewe, Laurence

AU - Lu, Yuan

AU - Kuderna, Lukas

AU - Minx, Patrick

AU - Montague, Michael J.

AU - Tomlinson, Chad

AU - Hillier, Ladeana W.

AU - Murphy, Daniel N.

AU - Wang, John

AU - Wang, Zhongwei

AU - Garcia, Constantino Macias

AU - Thomas, Gregg C.W.

AU - Volff, Jean Nicolas

AU - Farias, Fabiana

AU - Aken, Bronwen

AU - Walter, Ronald B.

AU - Pruitt, Kim D.

AU - Marques-Bonet, Tomas

AU - Hahn, Matthew W.

AU - Kneitz, Susanne

AU - Lynch, Michael

AU - Schartl, Manfred

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Clonal polymorphism and high heterozygosity in the celibate genome of the Amazon molly

Abstract

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