Clonal polymorphism and high heterozygosity in the celibate genome of the Amazon molly

Wesley C. Warren, Raquel García-Pérez, Sen Xu, Kathrin P. Lampert, Domitille Chalopin, Matthias Stöck, Laurence Loewe, Yuan Lu, Lukas Kuderna, Patrick Minx, Michael J. Montague, Chad Tomlinson, Ladeana W. Hillier, Daniel N. Murphy, John Wang, Zhongwei Wang, Constantino Macias Garcia, Gregg C.W. Thomas, Jean Nicolas Volff, Fabiana FariasBronwen Aken, Ronald B. Walter, Kim D. Pruitt, Tomas Marques-Bonet, Matthew W. Hahn, Susanne Kneitz, Michael Lynch, Manfred Schartl

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The extreme rarity of asexual vertebrates in nature is generally explained by genomic decay due to absence of meiotic recombination, thus leading to extinction of such lineages. We explore features of a vertebrate asexual genome, the Amazon molly, Poecilia formosa, and find few signs of genetic degeneration but unique genetic variability and ongoing evolution. We uncovered a substantial clonal polymorphism and, as a conserved feature from its interspecific hybrid origin, a 10-fold higher heterozygosity than in the sexual parental species. These characteristics seem to be a principal reason for the unpredicted fitness of this asexual vertebrate. Our data suggest that asexual vertebrate lineages are scarce not because they are at a disadvantage, but because the genomic combinations required to bypass meiosis and to make up a functioning hybrid genome are rarely met in nature.

Original languageEnglish (US)
Pages (from-to)669-679
Number of pages11
JournalNature Ecology and Evolution
Volume2
Issue number4
DOIs
StatePublished - Apr 1 2018
Externally publishedYes

Fingerprint

Poecilia formosa
heterozygosity
vertebrate
polymorphism
genome
vertebrates
genetic polymorphism
genomics
rarity
bypass
meiosis
recombination
fitness
extinction
deterioration
fold
genetic variation

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Ecology

Cite this

Warren, W. C., García-Pérez, R., Xu, S., Lampert, K. P., Chalopin, D., Stöck, M., ... Schartl, M. (2018). Clonal polymorphism and high heterozygosity in the celibate genome of the Amazon molly. Nature Ecology and Evolution, 2(4), 669-679. https://doi.org/10.1038/s41559-018-0473-y

Clonal polymorphism and high heterozygosity in the celibate genome of the Amazon molly. / Warren, Wesley C.; García-Pérez, Raquel; Xu, Sen; Lampert, Kathrin P.; Chalopin, Domitille; Stöck, Matthias; Loewe, Laurence; Lu, Yuan; Kuderna, Lukas; Minx, Patrick; Montague, Michael J.; Tomlinson, Chad; Hillier, Ladeana W.; Murphy, Daniel N.; Wang, John; Wang, Zhongwei; Garcia, Constantino Macias; Thomas, Gregg C.W.; Volff, Jean Nicolas; Farias, Fabiana; Aken, Bronwen; Walter, Ronald B.; Pruitt, Kim D.; Marques-Bonet, Tomas; Hahn, Matthew W.; Kneitz, Susanne; Lynch, Michael; Schartl, Manfred.

In: Nature Ecology and Evolution, Vol. 2, No. 4, 01.04.2018, p. 669-679.

Research output: Contribution to journalArticle

Warren, WC, García-Pérez, R, Xu, S, Lampert, KP, Chalopin, D, Stöck, M, Loewe, L, Lu, Y, Kuderna, L, Minx, P, Montague, MJ, Tomlinson, C, Hillier, LW, Murphy, DN, Wang, J, Wang, Z, Garcia, CM, Thomas, GCW, Volff, JN, Farias, F, Aken, B, Walter, RB, Pruitt, KD, Marques-Bonet, T, Hahn, MW, Kneitz, S, Lynch, M & Schartl, M 2018, 'Clonal polymorphism and high heterozygosity in the celibate genome of the Amazon molly', Nature Ecology and Evolution, vol. 2, no. 4, pp. 669-679. https://doi.org/10.1038/s41559-018-0473-y
Warren WC, García-Pérez R, Xu S, Lampert KP, Chalopin D, Stöck M et al. Clonal polymorphism and high heterozygosity in the celibate genome of the Amazon molly. Nature Ecology and Evolution. 2018 Apr 1;2(4):669-679. https://doi.org/10.1038/s41559-018-0473-y
Warren, Wesley C. ; García-Pérez, Raquel ; Xu, Sen ; Lampert, Kathrin P. ; Chalopin, Domitille ; Stöck, Matthias ; Loewe, Laurence ; Lu, Yuan ; Kuderna, Lukas ; Minx, Patrick ; Montague, Michael J. ; Tomlinson, Chad ; Hillier, Ladeana W. ; Murphy, Daniel N. ; Wang, John ; Wang, Zhongwei ; Garcia, Constantino Macias ; Thomas, Gregg C.W. ; Volff, Jean Nicolas ; Farias, Fabiana ; Aken, Bronwen ; Walter, Ronald B. ; Pruitt, Kim D. ; Marques-Bonet, Tomas ; Hahn, Matthew W. ; Kneitz, Susanne ; Lynch, Michael ; Schartl, Manfred. / Clonal polymorphism and high heterozygosity in the celibate genome of the Amazon molly. In: Nature Ecology and Evolution. 2018 ; Vol. 2, No. 4. pp. 669-679.
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