Clinicopathological findings following intraventricular glial-derived neurotrophic factor treatment in a patient with Parkinson's disease

Jeffrey H. Kordower; Stephane Palfi; Er Yun Chen; Shuang Y. Ma; Timothy Sendera; Elizabeth J. Cochran; Elliott J. Mufson; Richard Penn; Christopher G. Goetz; Cynthia D. Comella

doi:10.1002/1531-8249(199909)46:3<419::AID-ANA21>3.0.CO;2-Q

Clinicopathological findings following intraventricular glial-derived neurotrophic factor treatment in a patient with Parkinson's disease

Jeffrey H. Kordower, Stephane Palfi, Er Yun Chen, Shuang Y. Ma, Timothy Sendera, Elizabeth J. Cochran, Elliott J. Mufson, Richard Penn, Christopher G. Goetz, Cynthia D. Comella

Research output: Contribution to journal › Article › peer-review

369 Scopus citations

Abstract

As part of a safety and tolerability study, a 65-year-old man with Parkinson's disease (PD) received monthly intracerebroventricular injections of glial-derived neurotrophic factor (GDNF). His parkinsonism continued to worsen following intracerebroventricular GDNF treatment. Side effects included nausea, loss of appetite, tingling, L'hermitte's sign, intermittent hallucinations, depression, and inappropriate sexual conduct. There was no evidence of significant regeneration of nigrostriatal neurons or intraparenchymal diffusion of the intracerebroventricular GDNF to relevant brain regions. Alternative GDNF delivery systems should be explored.

Original language	English (US)
Pages (from-to)	419-424
Number of pages	6
Journal	Annals of Neurology
Volume	46
Issue number	3
DOIs	https://doi.org/10.1002/1531-8249(199909)46:3<419::AID-ANA21>3.0.CO;2-Q
State	Published - 1999
Externally published	Yes

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1002/1531-8249(199909)46:3<419::AID-ANA21>3.0.CO;2-Q

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Kordower, J. H., Palfi, S., Chen, E. Y., Ma, S. Y., Sendera, T., Cochran, E. J., Mufson, E. J., Penn, R., Goetz, C. G., & Comella, C. D. (1999). Clinicopathological findings following intraventricular glial-derived neurotrophic factor treatment in a patient with Parkinson's disease. Annals of Neurology, 46(3), 419-424. https://doi.org/10.1002/1531-8249(199909)46:3<419::AID-ANA21>3.0.CO;2-Q

Kordower, JH, Palfi, S, Chen, EY, Ma, SY, Sendera, T, Cochran, EJ, Mufson, EJ, Penn, R, Goetz, CG & Comella, CD 1999, 'Clinicopathological findings following intraventricular glial-derived neurotrophic factor treatment in a patient with Parkinson's disease', Annals of Neurology, vol. 46, no. 3, pp. 419-424. https://doi.org/10.1002/1531-8249(199909)46:3<419::AID-ANA21>3.0.CO;2-Q

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abstract = "As part of a safety and tolerability study, a 65-year-old man with Parkinson's disease (PD) received monthly intracerebroventricular injections of glial-derived neurotrophic factor (GDNF). His parkinsonism continued to worsen following intracerebroventricular GDNF treatment. Side effects included nausea, loss of appetite, tingling, L'hermitte's sign, intermittent hallucinations, depression, and inappropriate sexual conduct. There was no evidence of significant regeneration of nigrostriatal neurons or intraparenchymal diffusion of the intracerebroventricular GDNF to relevant brain regions. Alternative GDNF delivery systems should be explored.",

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AU - Kordower, Jeffrey H.

AU - Palfi, Stephane

AU - Chen, Er Yun

AU - Ma, Shuang Y.

AU - Sendera, Timothy

AU - Cochran, Elizabeth J.

AU - Mufson, Elliott J.

AU - Penn, Richard

AU - Goetz, Christopher G.

AU - Comella, Cynthia D.

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Clinicopathological findings following intraventricular glial-derived neurotrophic factor treatment in a patient with Parkinson's disease

Abstract

ASJC Scopus subject areas

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