Cliff-edged fitness functions and the persistence of schizophrenia

Randolph M. Nesse

doi:10.1017/S0140525X04300191

Cliff-edged fitness functions and the persistence of schizophrenia

Randolph M. Nesse

Research output: Contribution to journal › Article

30 Scopus citations

Abstract

Strong recent selection for social cognition may well explain the persistence of genes that predispose to schizophrenia. The specific mechanism responsible may be a skewed fitness function in which selection pushes the mean for advantageous mental traits perilously close to a "fitness cliff" where the system fails catastrophically in some individuals.

Original language	English (US)
Pages (from-to)	862-863
Number of pages	2
Journal	Behavioral and Brain Sciences
Volume	27
Issue number	6
DOIs	https://doi.org/10.1017/S0140525X04300191
State	Published - Dec 1 2004
Externally published	Yes

ASJC Scopus subject areas

Neuropsychology and Physiological Psychology
Physiology
Behavioral Neuroscience

Access to Document

10.1017/S0140525X04300191

Fingerprint Dive into the research topics of 'Cliff-edged fitness functions and the persistence of schizophrenia'. Together they form a unique fingerprint.

Cite this

Nesse, R. M. (2004). Cliff-edged fitness functions and the persistence of schizophrenia. Behavioral and Brain Sciences, 27(6), 862-863. https://doi.org/10.1017/S0140525X04300191

@article{9e6a803980ab4ff79bafb7e613357983,

title = "Cliff-edged fitness functions and the persistence of schizophrenia",

abstract = "Strong recent selection for social cognition may well explain the persistence of genes that predispose to schizophrenia. The specific mechanism responsible may be a skewed fitness function in which selection pushes the mean for advantageous mental traits perilously close to a {"}fitness cliff{"} where the system fails catastrophically in some individuals.",

author = "Nesse, {Randolph M.}",

year = "2004",

month = dec,

day = "1",

doi = "10.1017/S0140525X04300191",

language = "English (US)",

volume = "27",

pages = "862--863",

journal = "Behavioral and Brain Sciences",

issn = "0140-525X",

publisher = "Cambridge University Press",

number = "6",

}

TY - JOUR

T1 - Cliff-edged fitness functions and the persistence of schizophrenia

AU - Nesse, Randolph M.

PY - 2004/12/1

Y1 - 2004/12/1

N2 - Strong recent selection for social cognition may well explain the persistence of genes that predispose to schizophrenia. The specific mechanism responsible may be a skewed fitness function in which selection pushes the mean for advantageous mental traits perilously close to a "fitness cliff" where the system fails catastrophically in some individuals.

AB - Strong recent selection for social cognition may well explain the persistence of genes that predispose to schizophrenia. The specific mechanism responsible may be a skewed fitness function in which selection pushes the mean for advantageous mental traits perilously close to a "fitness cliff" where the system fails catastrophically in some individuals.

UR - http://www.scopus.com/inward/record.url?scp=21044458032&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=21044458032&partnerID=8YFLogxK

U2 - 10.1017/S0140525X04300191

DO - 10.1017/S0140525X04300191

M3 - Article

AN - SCOPUS:21044458032

VL - 27

SP - 862

EP - 863

JO - Behavioral and Brain Sciences

JF - Behavioral and Brain Sciences

SN - 0140-525X

IS - 6

ER -