Clathrin assembly protein AP-2 is detected in both neurons and glia, and its reduction is prominent in layer II of frontal cortex in Alzheimer's disease

Pamela J. Yao, Jill M. Weimer, Timothy M. O’Herron, Paul D. Coleman

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

There are several adaptor proteins associated with clathrin coated vesicles. Among them are AP180 and AP-2. We and others have previously described synaptic localization of AP180. AP180 immunoreactivity is altered in both the superior frontal gyrus and hippocampus in Alzheimer's disease (AD). We here investigate the location and alteration of another adaptor protein, AP-2. In contrast to AP180, we have found that AP-2 is expressed by both neurons and glia. Furthermore, the only noticeable change of AP-2 in AD is a loss of its immunoreactivity in layer II of the superior frontal gyrus.

Original languageEnglish (US)
Pages (from-to)921-929
Number of pages9
JournalNeurobiology of Aging
Volume21
Issue number6
DOIs
StatePublished - 2000
Externally publishedYes

Keywords

  • AP-2
  • Alzheimer's disease
  • Clathrin assembly protein
  • Endocytosis
  • Immunoblot analysis
  • Immunohistochemistry
  • Synaptic vesicle recycling

ASJC Scopus subject areas

  • Neuroscience(all)
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

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