Clathrin assembly protein AP-2 is detected in both neurons and glia, and its reduction is prominent in layer II of frontal cortex in Alzheimer's disease

Pamela J. Yao, Jill M. Weimer, Timothy M. O’Herron, Paul Coleman

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

There are several adaptor proteins associated with clathrin coated vesicles. Among them are AP180 and AP-2. We and others have previously described synaptic localization of AP180. AP180 immunoreactivity is altered in both the superior frontal gyrus and hippocampus in Alzheimer's disease (AD). We here investigate the location and alteration of another adaptor protein, AP-2. In contrast to AP180, we have found that AP-2 is expressed by both neurons and glia. Furthermore, the only noticeable change of AP-2 in AD is a loss of its immunoreactivity in layer II of the superior frontal gyrus.

Original languageEnglish (US)
Pages (from-to)921-929
Number of pages9
JournalNeurobiology of Aging
Volume21
Issue number6
DOIs
StatePublished - Jan 1 2000
Externally publishedYes

Fingerprint

Vesicular Transport Adaptor Proteins
Frontal Lobe
Prefrontal Cortex
Neuroglia
Alzheimer Disease
Clathrin-Coated Vesicles
Neurons
Parahippocampal Gyrus
Proteins

Keywords

  • Alzheimer's disease
  • AP-2
  • Clathrin assembly protein
  • Endocytosis
  • Immunoblot analysis
  • Immunohistochemistry
  • Synaptic vesicle recycling

ASJC Scopus subject areas

  • Neuroscience(all)
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

Cite this

Clathrin assembly protein AP-2 is detected in both neurons and glia, and its reduction is prominent in layer II of frontal cortex in Alzheimer's disease. / Yao, Pamela J.; Weimer, Jill M.; O’Herron, Timothy M.; Coleman, Paul.

In: Neurobiology of Aging, Vol. 21, No. 6, 01.01.2000, p. 921-929.

Research output: Contribution to journalArticle

@article{fc9bd6243a2d41f5a854b6ff46c7a3b0,
title = "Clathrin assembly protein AP-2 is detected in both neurons and glia, and its reduction is prominent in layer II of frontal cortex in Alzheimer's disease",
abstract = "There are several adaptor proteins associated with clathrin coated vesicles. Among them are AP180 and AP-2. We and others have previously described synaptic localization of AP180. AP180 immunoreactivity is altered in both the superior frontal gyrus and hippocampus in Alzheimer's disease (AD). We here investigate the location and alteration of another adaptor protein, AP-2. In contrast to AP180, we have found that AP-2 is expressed by both neurons and glia. Furthermore, the only noticeable change of AP-2 in AD is a loss of its immunoreactivity in layer II of the superior frontal gyrus.",
keywords = "Alzheimer's disease, AP-2, Clathrin assembly protein, Endocytosis, Immunoblot analysis, Immunohistochemistry, Synaptic vesicle recycling",
author = "Yao, {Pamela J.} and Weimer, {Jill M.} and O’Herron, {Timothy M.} and Paul Coleman",
year = "2000",
month = "1",
day = "1",
doi = "10.1016/S0197-4580(00)00228-1",
language = "English (US)",
volume = "21",
pages = "921--929",
journal = "Neurobiology of Aging",
issn = "0197-4580",
publisher = "Elsevier Inc.",
number = "6",

}

TY - JOUR

T1 - Clathrin assembly protein AP-2 is detected in both neurons and glia, and its reduction is prominent in layer II of frontal cortex in Alzheimer's disease

AU - Yao, Pamela J.

AU - Weimer, Jill M.

AU - O’Herron, Timothy M.

AU - Coleman, Paul

PY - 2000/1/1

Y1 - 2000/1/1

N2 - There are several adaptor proteins associated with clathrin coated vesicles. Among them are AP180 and AP-2. We and others have previously described synaptic localization of AP180. AP180 immunoreactivity is altered in both the superior frontal gyrus and hippocampus in Alzheimer's disease (AD). We here investigate the location and alteration of another adaptor protein, AP-2. In contrast to AP180, we have found that AP-2 is expressed by both neurons and glia. Furthermore, the only noticeable change of AP-2 in AD is a loss of its immunoreactivity in layer II of the superior frontal gyrus.

AB - There are several adaptor proteins associated with clathrin coated vesicles. Among them are AP180 and AP-2. We and others have previously described synaptic localization of AP180. AP180 immunoreactivity is altered in both the superior frontal gyrus and hippocampus in Alzheimer's disease (AD). We here investigate the location and alteration of another adaptor protein, AP-2. In contrast to AP180, we have found that AP-2 is expressed by both neurons and glia. Furthermore, the only noticeable change of AP-2 in AD is a loss of its immunoreactivity in layer II of the superior frontal gyrus.

KW - Alzheimer's disease

KW - AP-2

KW - Clathrin assembly protein

KW - Endocytosis

KW - Immunoblot analysis

KW - Immunohistochemistry

KW - Synaptic vesicle recycling

UR - http://www.scopus.com/inward/record.url?scp=0033638756&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033638756&partnerID=8YFLogxK

U2 - 10.1016/S0197-4580(00)00228-1

DO - 10.1016/S0197-4580(00)00228-1

M3 - Article

C2 - 11124443

AN - SCOPUS:0033638756

VL - 21

SP - 921

EP - 929

JO - Neurobiology of Aging

JF - Neurobiology of Aging

SN - 0197-4580

IS - 6

ER -